Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway

doi:10.3390/ph17050631

科研成果详情

题名	Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway
作者	Ji, Lijun1,2; Lou, Shuaijie1; Fang, Yi 1; Wang, Xu 1; Zhu, Weiwei 1; Liang, Guang1,3; Lee, Kwangyoul 2; Luo, Wu 1,3; Zhuang, Zaishou 1
发表日期	2024-05-01
发表期刊	Pharmaceuticals; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	diabetic cardiomyopathy fibrosis inflammation JAK2/STAT3 signaling pathway patchouli alcohol
其他关键词	DIASTOLIC DYSFUNCTION ; INSULIN-RESISTANCE ; CELL-LINE ; FAILURE ; ACTIVATION ; FIBROSIS ; JAK
摘要	Diabetic cardiomyopathy (DCM) represents a common pathological state brought about by diabetes mellitus (DM). Patchouli alcohol (PatA) is known for its diverse advantageous effects, notably its anti-inflammatory properties and protective role against metabolic disorders. Despite this, the influence of PatA on DCM remains relatively unexplored. To explore the effect of PatA on diabetes-induced cardiac injury and dysfunction in mice, streptozotocin (STZ) was used to mimic type 1 diabetes in mice. Serological markers and echocardiography show that PatA treatment protects the heart against cardiomyopathy by controlling myocardial fibrosis but not by reducing hyperglycemia in diabetic mice. Discovery Studio 2017 software was used to perform reverse target screening of PatA, and we found that JAK2 may be a potential target of PatA. RNA-seq analysis of heart tissues revealed that PatA activity in the myocardium was primarily associated with the inflammatory fibrosis through the Janus tyrosine kinase 2 (JAK2)/signal transducer and activator of the transcription 3 (STAT3) pathway. In vitro, we also found that PatA alleviates high glucose (HG) + palmitic acid (PA)-induced fibrotic and inflammatory responses via inhibiting the JAK2/STAT3 signaling pathway in H9C2 cells. Our findings illustrate that PatA mitigates the effects of HG + PA- or STZ-induced cardiomyopathy by acting on the JAK2/STAT3 signaling pathway. These insights indicate that PatA could potentially serve as a therapeutic agent for DCM treatment.
资助项目	National Natural Science Foundation of China[81971143,21961142009,81930108,82000793];Natural Science Foundation of Zhejiang Province[LY22H070004];Zhejiang Provincial Key Scientific Project[2021C03041];
出版者	MDPI
ISSN	1424-8247
EISSN	1424-8247
卷号	17 期号:5
DOI	10.3390/ph17050631
页数	19
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001231648200001
收录类别	SCOPUS ; SCIE ; PUBMED
URL	查看原文
PubMed ID	38794201
SCOPUSEID	2-s2.0-85194233478
通讯作者地址	[Luo, Wu]The Affiliated Cangnan Hospital and Chemical Biology Research Center,Wenzhou Medical University,Wenzhou,325000,China ; [Zhuang, Zaishou]The Affiliated Cangnan Hospital and Chemical Biology Research Center,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Molecular Medicine;Pharmaceutical Science;Drug Discovery
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213461
专题	药学院（分析测试中心）_生物有机与药物化学研究中心
通讯作者	Luo, Wu; Zhuang, Zaishou
作者单位	1.The Affiliated Cangnan Hospital and Chemical Biology Research Center,Wenzhou Medical University,Wenzhou,325000,China; 2.College of Pharmacy,Chonnam National University,Gwangju,61186,South Korea; 3.School of Pharmaceutical Sciences,Hangzhou Medical College,Hangzhou,311399,China
第一作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心
通讯作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心
第一作者的第一单位	药学院（分析测试中心）_生物有机与药物化学研究中心
推荐引用方式 GB/T 7714	Ji, Lijun,Lou, Shuaijie,Fang, Yi,et al. Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway[J]. Pharmaceuticals;,2024,17(5).
APA	Ji, Lijun., Lou, Shuaijie., Fang, Yi., Wang, Xu., Zhu, Weiwei., ... & Zhuang, Zaishou. (2024). Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway. Pharmaceuticals;, 17(5).
MLA	Ji, Lijun,et al."Patchouli Alcohol Protects the Heart against Diabetes-Related Cardiomyopathy through the JAK2/STAT3 Signaling Pathway".Pharmaceuticals; 17.5(2024).