Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation

doi:10.1016/j.intimp.2024.111609

科研成果详情

题名	Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation
作者	Zhang, Lingxi1,2; Wang, Jiong1,2; Xu, Tingxin2; Luo, Yue2; Cai, Zhaohong1; Jiang, Yongsheng3; Jin, Tianyang2; Bao, Hongdan1; Wang, Yi2,3
发表日期	2024-03-10
发表期刊	International immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Inflammation MAPK NF-κB Obesity Obesity-associated nephropathy Pyroptosis
其他关键词	INDUCED FATTY LIVER ; ADIPOSE-TISSUE ; APOPTOSIS ; PROGRESSION
摘要	Obesity is recognized as a major risk factor for chronic kidney disease (CKD), which is accompanied by increased renal lipid build-up, fibrosis, inflammation, apoptosis and pyroptosis. Bicyclol (BIC), a Chinese marketed hepatoprotective drug, has shown excellent anti-inflammatory, anti-fibrosis, anti-apoptotic, and lipid regulation effects in different animal models. In this study, we explored the role and mechanism of BIC in high-fat diet (HFD)-induced obesity-related nephropathy. Mice were fed with HFD for 24 weeks to develop obesity-related nephropathy, while mice in the BIC administration group were treated with BIC (50 mg/kg or 100 mg/kg, once every two days) at the last 12 weeks. We found that BIC treatment relieved the impairment of kidney structure and renal dysfunction caused by HFD. In addition, we found that BIC mitigated HFD-induced renal fibrosis, inflammation, apoptosis and pyroptosis by inhibiting JNK and NF-κB pathways. SV40-MES-13 cells treated with palmitate (PA) were used as the in vitro model. Our data show that BIC pre-administration relieved cellular damage caused by PA through suppressing JNK and NF-κB signaling pathways. In conclusion, we demonstrated that BIC attenuated obesity-induced renal injury by inhibiting chronic inflammation, fibrosis, apoptosis and pyroptosis via targeting JNK and NF-κB pathways. Our data suggested that BIC could be potentially used to prevent obesity-associated nephropathy, which warrants future investigation.
资助项目	Key Research Project of Wenzhou City[ZY2021021];National Natural Science Foundation of China[82170373];
出版者	ELSEVIER
ISSN	1567-5769
EISSN	1878-1705
卷号	129
DOI	10.1016/j.intimp.2024.111609
页数	11
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001188382700001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38364742
SCOPUSEID	2-s2.0-85185823512
通讯作者地址	[Bao, Hongdan]The Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,315700,China
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207639
专题	其他_附属萧山医院（杭州市萧山区第一人民医院）药学院（分析测试中心）药学院（分析测试中心）_生物有机与药物化学研究中心其他_附属象山医院（象山县第一人民医院）
通讯作者	Bao, Hongdan
作者单位	1.Department of Endocrinology,the Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,315700,China; 2.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.Joint Research Center on Medicine,the Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,315700,China
第一作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）; 药学院（分析测试中心）; 生物有机与药物化学研究中心
通讯作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）
第一作者的第一单位	附属萧山医院（杭州市萧山区第一人民医院）
推荐引用方式 GB/T 7714	Zhang, Lingxi,Wang, Jiong,Xu, Tingxin,et al. Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation[J]. International immunopharmacology,2024,129.
APA	Zhang, Lingxi., Wang, Jiong., Xu, Tingxin., Luo, Yue., Cai, Zhaohong., ... & Wang, Yi. (2024). Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation. International immunopharmacology, 129.
MLA	Zhang, Lingxi,et al."Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation".International immunopharmacology 129(2024).