Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway

doi:10.1016/j.intimp.2024.111551

科研成果详情

题名	Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway
作者	Qian, Chenchen1,2; Xu, Diyun 2; Wang, Jiong2; Luo, Yue2; Jin, Tianyang2; Huang, Lijiang1; Zhou, Yafen 1; Cai, Zhaohong1; Jin, Bo2; Bao, Hongdan1; Wang, Yi1,2,3
发表日期	2024-02-15
发表期刊	International immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Cardiomyocyte Inflammation Obesity-induced cardiomyopathy TLR2
其他关键词	ACTIVATION ; DYSFUNCTION ; MANAGEMENT ; FAILURE ; INJURY
摘要	Growing evidence demonstrates that chronic low-grade inflammation, which is induced by high-fat diet (HFD) or saturated fatty acid, plays an important role in the obesity-induced cardiomyopathy (OIC) process. Moreover, obesity is associated with the activation of different inflammatory pathways, including nuclear factor-κB (NF-κB), Toll-like-receptor-2 (TLR2) and Toll-like-receptor-4 (TLR4). In this study, we established an HFD-induced cardiac injury mouse model and palmitate (PA)-induced myocardial cell model to evaluate the role of TLR2 in OIC. Our data show that TLR2 blockade using TLR2 knockout (KO) mice or a TLR2-specific inhibitor, C29, markedly ameliorated HFD- or PA-induced inflammation, myocardial fibrosis, and hypertrophy both in vivo and in vitro. Moreover, the PA-induced myocardial cell injury was mediated via inducing the formation of TLR2-MyD88 complex in a TLR4-independent manner in cardiomyocytes. Our data prove the critical role of cardiac TLR2 in the pathogenesis of HFD- and saturated fatty acid-induced myocarditis, fibrosis, myocardial hypertrophy, and cardiac dysfunction. Inhibition of TLR2 pathway may be a therapeutic strategy of OIC.
资助项目	Key Research Project of Wenzhou City[ZY2021021];National Natural Science Foundation of China[81970338,82170373];Medical and Health Science Research Project of Zhejiang Province[2023XY164];
出版者	ELSEVIER
ISSN	1567-5769
EISSN	1878-1705
卷号	128
DOI	10.1016/j.intimp.2024.111551
页数	11
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001173294800001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38278067
SCOPUSEID	2-s2.0-85183521790
通讯作者地址	[Bao, Hongdan]Joint Research Center on Medicine,The Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,China
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207507
专题	其他_附属萧山医院（杭州市萧山区第一人民医院）药学院（分析测试中心）药学院（分析测试中心）_生物有机与药物化学研究中心其他_附属象山医院（象山县第一人民医院）
通讯作者	Bao, Hongdan
作者单位	1.Joint Research Center on Medicine,The Affiliated Xiangshan Hospital of Wenzhou Medical University,Zhejiang,Ningbo,China; 2.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.School of Pharmacy,Hangzhou Normal University,Zhejiang,Hangzhou,China
第一作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）; 药学院（分析测试中心）; 生物有机与药物化学研究中心
通讯作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）
第一作者的第一单位	附属萧山医院（杭州市萧山区第一人民医院）
推荐引用方式 GB/T 7714	Qian, Chenchen,Xu, Diyun,Wang, Jiong,et al. Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway[J]. International immunopharmacology,2024,128.
APA	Qian, Chenchen., Xu, Diyun., Wang, Jiong., Luo, Yue., Jin, Tianyang., ... & Wang, Yi. (2024). Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway. International immunopharmacology, 128.
MLA	Qian, Chenchen,et al."Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway".International immunopharmacology 128(2024).