Mitochondrial Lon Protease and Cancer

doi:10.1007/978-981-10-6674-0_12

科研成果详情

题名	Mitochondrial Lon Protease and Cancer
作者	Lu, Bin 1,2
发表日期	2017
发表期刊	Advances in experimental medicine and biology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Research Support, Non-U.S. Gov't ; Review
关键词	Anticancer drug Cancer Lon Mitochondria Protein degradation Protein quality control
其他关键词	ATP-DEPENDENT PROTEASE ; ESCHERICHIA-COLI ; OXIDATIVE STRESS ; CYCLE ARREST ; DNA-BINDING ; APOPTOSIS ; CELLS ; DEGRADATION ; MAINTENANCE ; INVOLVEMENT
摘要	ATP-dependent Lon protease of mitochondrial matrix is encoded by nuclear DNA and highly evolutionarily conserved throughout all organisms, which is involved in the quality control of proteins by selective degradation of misfolded, oxidized, and short-lived regulatory proteins within mitochondrial matrix, maintenance of mitochondrial genome (mtDNA), and folding of mitochondria proteins. Various stimuli such as hypoxia and oxidative and ER stress lead to upregulation of Lon expression. Inhibition of protease activity or downregulation of Lon promotes cancer cell death and enhances sensitivity of cancer cells to anticancer drugs through metabolic reprogramming, thus reducing the viability of cancer cell in tumor microenvironment and epithelial to mesenchymal transition (EMT). Moreover, mitochondrial ATP-dependent Lon protease may serve as a potential biomarker for cancer diagnosis and novel target for the development of anticancer drugs and for predicting of the efficiency and effectiveness of chemotherapy of a variety of cancers.
资助项目	National Basic Research Program of China (973 Program) [2013CB531700]; National Natural Science Foundation of China [31070710, 31171345, 31570772, 31771543]; Zhejiang Qianjiang Talent Project B [2010R10045]
出版者	SPRINGER-VERLAG SINGAPORE PTE LTD
ISSN	0065-2598
EISSN	2214-8019
卷号	1038 页码:173-182
DOI	10.1007/978-981-10-6674-0_12
页数	10
WOS类目	Cell Biology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS研究方向	Cell Biology ; Genetics & Heredity ; Research & Experimental Medicine
WOS记录号	WOS:000674144500012
收录类别	PUBMED ; BKCI-S ; SCIE
URL	查看原文
PubMed ID	29178076
通讯作者地址	[Lu, Bin]Wenzhou Med Univ, Attardi Inst Mitochondrial Biomed, Inst Biophys, Wenzhou, Zhejiang, Peoples R China. ; [Lu, Bin]Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/186063
专题	检验医学院（生命科学学院、生物学实验教学中心）检验医学院（生命科学学院、生物学实验教学中心）_Attardei线粒体研究院
通讯作者	Lu, Bin
作者单位	1.Wenzhou Med Univ, Attardi Inst Mitochondrial Biomed, Inst Biophys, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Sch Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou, Zhejiang, Peoples R China
第一作者单位	温州医科大学; 检验医学院（生命科学学院、生物学实验教学中心）
通讯作者单位	温州医科大学; 检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Lu, Bin. Mitochondrial Lon Protease and Cancer[J]. Advances in experimental medicine and biology,2017,1038:173-182.
APA	Lu, Bin. (2017). Mitochondrial Lon Protease and Cancer. Advances in experimental medicine and biology, 1038, 173-182.
MLA	Lu, Bin."Mitochondrial Lon Protease and Cancer".Advances in experimental medicine and biology 1038(2017):173-182.