Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors

doi:10.1016/j.bmcl.2011.12.094

科研成果详情

题名	Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors
作者	Song, Bo 1; Xiao, Tong1; Qi, Xiaolu 1; Li, Ling-Na 1; Qin, Kuiyou 1; Nian, Siyun 1; Hu, Guo-Xin1; Yu, Yinfei2; Liang, Guang1,3; Ye, Faqing1,3
发表日期	2012-02-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Monoamine oxidase-B inhibitors Xanthine derivative Parkinson's disease Neuroportective effect Inhibitory effect
摘要	Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson's disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound 6a having a K-i value of 0.26 mu M. Their promising activity in vitro suggests potential use in the treatment of PD. (C) 2012 Elsevier Ltd. All rights reserved.
资助项目	Zhejiang Science & Technology Funding [Y2080697, Y204089]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0960-894X
EISSN	1464-3405
卷号	22 期号:4 页码:1739-1742
DOI	10.1016/j.bmcl.2011.12.094
页数	4
WOS类目	Chemistry, Medicinal ; Chemistry, Organic
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
WOS记录号	WOS:000300404900054
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	22257893
SCOPUSEID	2-s2.0-84862799939
通讯作者地址	[Ye, Faqing]Wenzhou Med Coll, Sch Pharm, Wenzhou 325000, Peoples R China.
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14414
专题	药学院（分析测试中心）眼视光学院（生物医学工程学院）、附属眼视光医院药学院（分析测试中心）_生物有机与药物化学研究中心
通讯作者	Ye, Faqing
作者单位	1.Wenzhou Med Coll, Sch Pharm, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Coll, Affiliated Eye Hosp, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Coll, Bioorgan & Med Chem Res Ctr, Wenzhou 325000, Peoples R China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Song, Bo,Xiao, Tong,Qi, Xiaolu,et al. Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(4):1739-1742.
APA	Song, Bo., Xiao, Tong., Qi, Xiaolu., Li, Ling-Na., Qin, Kuiyou., ... & Ye, Faqing. (2012). Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(4), 1739-1742.
MLA	Song, Bo,et al."Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.4(2012):1739-1742.