Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection

doi:10.1002/anie.201410720

科研成果详情

题名	Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection
作者	Lin, Meihua 1,2; Wang, Jingjing 1,2; Zhou, Guobao 1,2,4; Wang, Jianbang 1,2,3; Wu, Na 1,2; Lu, Jianxin 3; Gao, Jimin3; Chen, Xiaoqing 4; Shi, Jiye 1,2,5; Zuo, Xiaolei 1,2; Fan, Chunhai 1,2
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	biosensors DNA nanostructures electrochemistry soft lithography surface chemistry
其他关键词	ELECTROCHEMICAL INTERROGATION ; SOFT LITHOGRAPHY ; DETECTION LIMITS ; GOLD ; HYBRIDIZATION ; NANOFABRICATION ; DIAGNOSTICS ; DIFFUSION ; NANOWIRE ; ORIGAMI
摘要	Self-assembled DNA nanostructures with precise sizes allow a programmable soft lithography approach to engineer the interface of electrochemical DNA sensors. By using millimeter-sized gold electrodes modified with several types of tetrahedral DNA nanostructures (TDNs) of different sizes, both the kinetics and thermodynamics of DNA hybridization were profoundly affected. Because each DNA probe is anchored on an individual TDN, its lateral spacing and interactions are finely tuned by the TDN size. By simply varying the size of the TDNs, the hybridization time was decreased and the hybridization efficiency was increased. More significantly, the detection limit for DNA detection was tuned over four orders of magnitude with differentially nanostructured electrodes, and achieved attomolar sensitivity with polymeric enzyme amplification.
资助项目	National Basic Research Program (973 Program)National Basic Research Program of China [2012CB932600, 2013CB932803]; NSFCNational Natural Science Foundation of China (NSFC) [91313302, 21390414, 21422508, 21329501]; Shanghai Pujiang ProjectShanghai Pujiang Program [13PJ1410700]; Chinese Academy of SciencesChinese Academy of Sciences
出版者	WILEY-V C H VERLAG GMBH
出版地	WEINHEIM
ISSN	1433-7851
EISSN	1521-3773
卷号	54 期号:7 页码:2151-2155
DOI	10.1002/anie.201410720
页数	38
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000349391000023
收录类别	SCIE ; EI ; SCOPUS
发表日期	2015-02-09
EI入藏号	20150700515362
EI主题词	DNA
URL	查看原文
Scopus记录号	2-s2.0-84922470863
ESI高被引论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
自科自定义期刊分类	T3(A)类
引用统计	被引频次：279[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9923
专题	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者	Zuo, Xiaolei
作者单位	1.Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China; 2.Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China; 3.Wenzhou Med Univ, Sch Med Lab Sci & Life Sci, Wenzhou 325035, Zhejiang, Peoples R China; 4.Cent S Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Resource Conserving & Envi, Changsha 410083, Hunan, Peoples R China; 5.UCB Pharma, Slough SL1 4EN, Berks, England
推荐引用方式 GB/T 7714	Lin, Meihua,Wang, Jingjing,Zhou, Guobao,et al. Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(7):2151-2155.
APA	Lin, Meihua., Wang, Jingjing., Zhou, Guobao., Wang, Jianbang., Wu, Na., ... & Fan, Chunhai. (2015). Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(7), 2151-2155.
MLA	Lin, Meihua,et al."Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.7(2015):2151-2155.