Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese

doi:10.1371/journal.pone.0018398

科研成果详情

题名	Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese
作者	Lin, Zhuofeng1,2; Zhou, Zhihong3; Liu, Yanlong1; Gong, Qi1; Yan, Xinxin 1; Xiao, Jian1; Wang, Xiaojie 1; Lin, Shaoqiang1; Feng, Wenke1,5; Li, Xiaokun1,4
发表日期	2011-04-15
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	FIBROBLAST-GROWTH-FACTOR ; LEFT-VENTRICULAR HYPERTROPHY ; SERUM CYSTATIN-C ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; INSULIN SENSITIVITY ; FIBROBLAST-GROWTH-FACTOR-23 ; BETA-2-MICROGLOBULIN ; OBESITY ; HEALTH
摘要	Background: Fibroblast growth factor 21 (FGF21) is a hepatic hormone involved in the regulation of lipid and carbohydrate metabolism. This study aims to test the hypothesis that elevated FGF21 concentrations are associated with the change of renal function and the presence of left ventricular hypertrophy (LVH) in the different stages of chronic kidney disease (CKD) progression. Methodology/Principal Findings: 240 subjects including 200 CKD patients (146 outpatients and 54 long-term hemodialytic patients) and 40 healthy control subjects were recruited. All CKD subjects underwent echocardiograms to assess left ventricular mass index. Plasma FGF21 levels and other clinical and biochemical parameters in all subjects were obtained based on standard clinical examination methods. Plasma FGF21 levels were significantly increased with the development of CKD from early-and end-stage (P < 0.001 for trend), and significantly higher in CKD subjects than those in healthy subjects (P < 0.001). Plasma FGF21 levels in CKD patients with LVH were higher than those in patients without LVH (P=0.001). Furthermore, plasma FGF21 level correlated positively with creatinine, blood urea nitrogen (BUN), beta 2 microglobulin, systolic pressure, adiponectin, phosphate, proteinuria, CRP and triglyceride, but negatively with creatinine clearance rate (CCR), estimated glomerular filtrate rate (eGFR), HDL-c, LDL-c, albumin and LVH after adjusting for BMI, gender, age and the presence of diabetes mellitus. Multiple stepwise regression analyses indicated that FGF21 was independently associated with BUN, Phosphate, LVMI and beta 2 microglobulin (all P < 0.05). Conclusion: Plasma FGF21 levels are significantly increased with the development of early-to end-stage CKD and are independently associated with renal function and adverse lipid profiles in Chinese population. Understanding whether increased FGF21 is associated with myocardial hypertrophy in CKD requires further study.
资助项目	Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT); Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [R2090550, Y2100048]; Natural Science Grant of Zhejiang Province, China [2009J1-C451]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	6 期号:4 页码:e18398.
DOI	10.1371/journal.pone.0018398
页数	9
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000289578600008
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	21525989
PMC记录号	PMC3078122
SCOPUSEID	2-s2.0-79954525448
通讯作者地址	[Li, Xiaokun]School of Pharmacy,Wenzhou Medical College,China
Scopus学科分类	Multidisciplinary
引用统计	被引频次：75[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/9896
专题	药学院（分析测试中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院研究生工作部（研究生院）
通讯作者	Li, Xiaokun
作者单位	1.School of Pharmacy,Wenzhou Medical College,China; 2.School of Pharmacy,Jinan University,China; 3.Division of Kidney, the 2nd Affiliated Hospital,Wenzhou Medical College,China; 4.The Key Lab of Pathobiology,National Ministry of Education,Jilin University,China; 5.School of Medicine,University of Louisville,United States
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Lin, Zhuofeng,Zhou, Zhihong,Liu, Yanlong,et al. Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese[J]. PLOS ONE,2011,6(4):e18398..
APA	Lin, Zhuofeng., Zhou, Zhihong., Liu, Yanlong., Gong, Qi., Yan, Xinxin., ... & Li, Xiaokun. (2011). Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese. PLOS ONE, 6(4), e18398..
MLA	Lin, Zhuofeng,et al."Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese".PLOS ONE 6.4(2011):e18398..