TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kB signaling

doi:10.18632/aging.202290

科研成果详情

题名	TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kB signaling
作者	Lin, Ke1,2; Luo, Wu1; Yan, Jueqian 1; Shen, Siyuan1,2; Shen, Qirui 1; Wang, Jun 3; Guan, Xinfu 4; Wu, Gaojun2; Huang, Weijian2; Liang, Guang1,2,4
发表日期	2021
发表期刊	Aging 影响因子和分区
语种	英语
原始文献类型	Article
关键词	angiotensin II endothelial to mesenchymal transition NF-kB TLR2 vascular remodeling
摘要	Excessive vascular remodeling has been shown in hypertensive patients. In experimental models of hypertensive vascular injury, such as angiotensin II (Ang II) challenged mice, toll like receptor 2 (TLR2) initiates inflammatory responses. More recently, studies have reported atypical endothelial to mesenchymal transition (EndMT) in vascular injuries and inflammatory conditions. Here, we aimed to investigate whether TLR2 mediates Ang II-induced vascular inflammation and initiates EndMT. In a mouse model of angiotensin II-induced hypertension, we show that aortas exhibit increased medial thickening, fibrosis, and features of EndMT. These alterations were not observed in TLR2 knockout mice in response to Ang II. TLR2 silencing in cultured endothelial cells confirmed the essential role of TLR2 in Ang II-induced inflammatory factor induction, and EndMT-associated phenotypic change. Mechanistically, we found Ang II activates nuclear factor-KB signaling, inducing pro-inflammatory cytokine production, and mediates EndMT in both cultured endothelial cells and in mice. These studies illustrate a novel role of TLR2 in regulating Ang II-induced deleterious vascular remodeling through the induction of EndMT. The studies also suggest that TLR2 may be targeted to alleviate hypertension-associated vascular injury.
资助项目	National Natural Science Foundation of China[2017YFA0506000];
出版者	Impact Journals LLC
ISSN	1945-4589
卷号	13 期号:2 页码:2553-2574
DOI	10.18632/aging.202290
收录类别	SCOPUS ; PUBMED
URL	查看原文
PubMed ID	33318302
SCOPUSEID	2-s2.0-85100440527
通讯作者地址	[Liang, Guang]Affiliated Cangnan Hospital,Wenzhou Medical University,Cangnan,325800,China ; [Huang, Weijian]Department of Cardiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Aging;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/98545
专题	附属第一医院药学院（分析测试中心）其他_附属苍南医院（苍南县人民医院）
通讯作者	Huang, Weijian; Liang, Guang
作者单位	1.Chemical Biology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Cardiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Cardiology,Wenzhou Central Hospital and Affiliated Dingli Clinical Institute,Wenzhou Medical University,Wenzhou,325035,China; 4.Affiliated Cangnan Hospital,Wenzhou Medical University,Cangnan,325800,China
第一作者单位	药学院（分析测试中心）; 生物有机与药物化学研究中心; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属苍南医院（苍南县人民医院）; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Lin, Ke,Luo, Wu,Yan, Jueqian,et al. TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kB signaling[J]. Aging,2021,13(2):2553-2574.
APA	Lin, Ke., Luo, Wu., Yan, Jueqian., Shen, Siyuan., Shen, Qirui., ... & Liang, Guang. (2021). TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kB signaling. Aging, 13(2), 2553-2574.
MLA	Lin, Ke,et al."TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kB signaling".Aging 13.2(2021):2553-2574.