Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases

doi:10.3969/j.issn.1007-9572.2017.18.007

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题名	Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases
其他题名	Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases
作者	Zhou, Zhen-Ni 1; Li, Fang 2; Huang, De-Yi 2; Qian, Xu-Heng 3; Wang, Shi-Jia3; Xia, Xiao-Ru4
发表日期	2017-06-01
发表期刊	Chinese General Practice 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Arthritis, rheumatoid Comorbidity Root cause analysis
其他关键词	Arthritis ; rheumatoid ; Comorbidity ; Root cause analysis
摘要	Objective: To explore the clinical features and associated factors in rheumatoid arthritis(RA) patients with comorbidities, so as to provide a reference for comprehensively assessing the prognosis and delivering medical services for these patients. Methods: The enrolled participants were 223 cases with RA diagnosed and treated in Department of Rheumatism and Immunology of the First Affiliated Hospital of Wenzhou Medical University between January and December 2013. We reviewed their clinical data, recorded their baseline characteristics(results of laboratory and imaging examinations), status of comorbidities, and analyzed the associated factors of RA and the correlations between them. Results: Comorbidities were found in 84.8%(189/233) of the participants, which mainly included 16 different diseases, such as hyperlipidemia (41.3%, 92/233), hypertension (40.8%, 91/233), osteoporosis or osteopenia(24.7%, 55/233), diabetes (17.5%, 39/233), hyperuricemia (13.9%, 31/233), urinary calculi (13.5%, 30/233) and so on. Hyperlipidemia in RA had straight line correlation with Disease Activity Score 28(DAS28) (rs=-0.146, P<0.05), ESR (rs=-0. 153, P<0.05), blood pressure (rs=0.194, P<0.05), serum uric acid (rs=0.216, P<0.05); hypertension in RA had straight line correlation with age (rs=0.353, P<0.05), TJC (rs=0.161, P<0.05), SJC (rs=0.148, P<0.05), fasting blood glucose (rs=0.290, P<0.05), blood lipid (rs=0.194, P<0.05), serum uric acid (rs=0.220, P<0.05), abnormal bone mineral density (rs=0.202, P<0.05); osteoporosis or osteopenia in RA had linear correlation with male (rs=-0.173, P<0.05), age (rs=0.362, P<0.05), blood pressure (rs=0.202, P<0.05); diabetes in RA had straight line correlation with age (rs=0.245, P<0.05), TJC (rs=0.145, P<0.05), DAS28 (rs=0.182, P<0.05), CRP (rs=0.195, P<0.05), blood pressure (rs=0.290, P<0.05); hyperuricemia in RA had straight line correlation with male(rs=0.141, P<0.05), age (rs=0.172, P<0.05), blood pressure (rs=0.220, P<0.05), blood lipid (rs=0.216, P<0.05); urinary calculi in RA had straight line correlation with CRP (rs=0.135, P<0.05). Multivariate Logistic regression analysis showed that blood pressure and serum uric acid were the risk factors of RA combined with hyperlipidemia (P<0.05); age, fasting blood glucose, blood lipid and serum uric acid were the risk factors of RA with hypertension(P<0.05); female and age were the risk factors of RA with osteoporosis or osteopenia (P<0.05); course of RA, CRP and blood pressure were the risk factors of diabetes in RA (P<0.05); male, blood pressure and blood lipid were the risk factors of RA and hyperuricemia coexistence(P<0.05). Conclusion: Due to gender, age, abnormal blood pressure and blood lipid, patients with RA are prone to such comorbidities as hyperlipidemia, hypertension, osteoporosis, diabetes, hyperuricemia and so on, which would worsen the outcome and decrease the quality of life. Therefore, in order to better improve the prognosis of RA and reduce the associated consequences of comorbidities, a ample understanding, screening and effective management are needed in comorbidities in RA besides the clinical active treatment of RA.
其他摘要	Objective To explore the clinical features and associated factors in rheumatoid arthritis(RA) patients with comorbidities,so as to provide a reference for comprehensively assessing the prognosis and delivering medical services for these patients.Methods The enrolled participants were 223 cases with RA diagnosed and treated in Department of Rheumatism and Immunology of the First Affiliated Hospital of Wenzhou Medical University between January and December 2013.We reviewed their clinical data,recorded their baseline characteristics(results of laboratory and imaging examinations),status of comorbidities,and analyzed the associated factors of RA and the correlations between them.Results Comorbidities were found in 84.8%(189/233) of the participants,which mainly included 16 different diseases,such as hyperlipidemia (41.3%,92/233),hypertension (40.8%,91/233),osteoporosis or osteopenia(24.7%,55/233),diabetes (17.5%,39/233),hyperuricemia (13.9%,31/233),urinary calculi (13.5%,30/233) and so on.Hyperlipidemia in RA had straight line correlation with Disease Activity Score 28(DAS28) (rs=-0.146,P<0.05),ESR (rs=-0.153,P<0.05),blood pressure (rs=0.194,P<0.05),serum uric acid (rs=0.216,P<0.05);hypertension in RA had straight line correlation with age (rs=0.353,P<0.05),TJC (rs=0.161,P<0.05),SJC (rs=0.148,P<0.05),fasting blood glucose (rs=0.290,P<0.05),blood lipid (rs=0.194,P<0.05),serum uric acid (rs=0.220,P<0.05),abnormal bone mineral density (rs=0.202,P<0.05);osteoporosis or osteopenia in RA had linear correlation with male (rs=-0.173,P<0.05),age (rs=0.362,P<0.05),blood pressure (rs=0.202,P<0.05);diabetes in RA had straight line correlation with age (rs=0.245,P<0.05),TJC (rs=0.145,P<0.05),DAS28 (rs=0.182,P<0.05),CRP (rs=0.195,P<0.05),blood pressure (rs=0.290,P<0.05);hyperuricemia in RA had straight line correlation with male(rs=0.141,P<0.05),age (rs=0.172,P<0.05),blood pressure (rs=0.220,P<0.05),blood lipid (rs=0.216,P<0.05);urinary calculi in RA had straight line correlation with CRP (rs=0.135,P<0.05).Multivariate Logistic regression analysis showed that blood pressure and serum uric acid were the risk factors of RA combined with hyperlipidemia (P<0.05);age,fasting blood glucose,blood lipid and serum uric acid were the risk factors of RA with hypertension(P<0.05);female and age were the risk factors of RA with osteoporosis or osteopenia (P<0.05);course of RA,CRP and blood pressure were the risk factors of diabetes in RA (P<0.05);male,blood pressure and blood lipid were the risk factors of RA and hyperuricemia coexistence(P<0.05).Conclusion Due to gender,age,abnormal blood pressure and blood lipid,patients with RA are prone to such comorbidities as hyperlipidemia,hypertension,osteoporosis,diabetes,hyperuricemia and so on,which would worsen the outcome and decrease the quality of life.Therefore,in order to better improve the prognosis of RA and reduce the associated consequences of comorbidities,a ample understanding,screening and effective management are needed in comorbidities in RA besides the clinical active treatment of RA.
出版者	Chinese General Practice907, Guangyi BuildingNo. 5 Guangyi StreetBeijingBeijing
ISSN	1007-9572
卷号	20 期号:18 页码:2201-2207
DOI	10.3969/j.issn.1007-9572.2017.18.007
页数	7
收录类别	SCOPUS ; 万方 ; PKU ; 北大核心 ; ISTIC
URL	查看原文
SCOPUSEID	2-s2.0-85049811074
通讯作者地址	[Xia, Xiao-Ru]Department of Rheumatism and Immunology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Medicine (miscellaneous);Public Health, Environmental and Occupational Health;Family Practice
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/98404
专题	温州医科大学附属第一医院
通讯作者	Xia, Xiao-Ru
作者单位	1.Department of Internal Medicine,Yueqing People's Hospital,Yueqing,325600,China; 2.Department of Medical Imaging,The People's Hospital of Yuhuan,Yuhuan,317600,China; 3.Wenzhou Medical University,Wenzhou,325000,China; 4.Department of Rheumatism and Immunology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Zhen-Ni,Li, Fang,Huang, De-Yi,et al. Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases[J]. Chinese General Practice,2017,20(18):2201-2207.
APA	Zhou, Zhen-Ni, Li, Fang, Huang, De-Yi, Qian, Xu-Heng, Wang, Shi-Jia, & Xia, Xiao-Ru. (2017). Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases. Chinese General Practice, 20(18), 2201-2207.
MLA	Zhou, Zhen-Ni,et al."Clinical Features and Associated Factors of Rheumatoid Arthritis with Comorbidities in 223 Cases".Chinese General Practice 20.18(2017):2201-2207.

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