Mutations of mitochondrial tRNA<sup>ser(UCN)</sup> and their connection with hearing loss

doi:10.3760/cma.j.issn.1003-9406.2017.01.030

科研成果详情

题名	Mutations of mitochondrial tRNA^ser(UCN) and their connection with hearing loss
其他题名	Mutations of mitochondrial tRNA~(Ser(UCN)) and their connection with hearing loss
作者	Fan, Wenlu 1; Tang, Xiaoiven 1; Zheng, Binjiao 1; Guan, Minxin1,2; Xue, Ling1
发表日期	2017-02-01
发表期刊	Chinese Journal of Medical Genetics 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Hearing loss Mechanism Mitochondrial tRNA ser(UCN) Mutation
其他关键词	Hearing loss ; Mitochondrial tRNASer(UCN) ; Mutation ; Mechanism
摘要	Mitochondrial tRNAser(UCN) gene mutation is closely related to acoustic nerve deafness. Some mutations can affect the structure and transcriptional processing of tRNAser(UCN) , for instance m. 7444G>A mutation in tRNAser(UCN) precursor 3' side, m. 7472 insC as well as m. 7511T>C mutations in the stem and ring of tRNAser(UCN) , may influence tRNAser(UCN) stability, thus affect the synthesis of mitochondrial peptides, reduce the production of ATP and cause deafness. This article focuses on mitochondrial tRNAser(UCN) gene mutations as well as the mechanism underlying hearing loss.
其他摘要	Mitochondrial tRNA~(Ser(UCN)) gene mutation is closely related to acoustic nerve deafness.Some mutations can affect the structure and transcriptional processing of tRNA~(Ser(UCN)),for instance m.7444G>A mutation in tRNA~(Ser(UCN)) precursor 3' side, m.7472 insC as well as m.7511T>C mutations in the stem and ring of tRNA~(Ser(UCN)),may influence tRNA~(Ser(UCN)) stability, thus affect the synthesis of mitochondrial peptides, reduce the production of ATP and cause deafness.This article focuses on mitochondrial tRNA~(Ser(UCN)) gene mutations as well as the mechanism underlying hearing loss.
资助项目	国家自然科学基金青年科学基金 ; 浙江省自然科学基金 ; 浙江省医药卫生科技计划项目 ; 温州医学院科研发展基金
出版者	West China University of Medical Scienceszhyc@chinajournal.net.cn
ISSN	1003-9406
卷号	34 期号:1 页码:128-132
DOI	10.3760/cma.j.issn.1003-9406.2017.01.030
页数	5
收录类别	SCOPUS ; CSCD ; 万方 ; PUBMED ; ISTIC ; PKU ; 北大核心
学科领域	医药、卫生
URL	查看原文
CSCD记录号	CSCD:5941769
PubMed ID	28186612
SCOPUSEID	2-s2.0-85021858895
通讯作者地址	[Xue, Ling]Attardi Institute of Mitochondrial Biomedicine,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/98347
专题	检验医学院（生命科学学院、生物学实验教学中心）_Attardei线粒体研究院
通讯作者	Xue, Ling
作者单位	1.Attardi Institute of Mitochondrial Biomedicine,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 2.Institute of Genetics,School of Medicine,Zhejiang University,Hangzhou, Zhejiang,310058,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）_Attardei线粒体研究院
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）_Attardei线粒体研究院
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）_Attardei线粒体研究院
推荐引用方式 GB/T 7714	Fan, Wenlu,Tang, Xiaoiven,Zheng, Binjiao,et al. Mutations of mitochondrial tRNA^ser(UCN) and their connection with hearing loss[J]. Chinese Journal of Medical Genetics,2017,34(1):128-132.
APA	Fan, Wenlu, Tang, Xiaoiven, Zheng, Binjiao, Guan, Minxin, & Xue, Ling. (2017). Mutations of mitochondrial tRNA^ser(UCN) and their connection with hearing loss. Chinese Journal of Medical Genetics, 34(1), 128-132.
MLA	Fan, Wenlu,et al."Mutations of mitochondrial tRNA^ser(UCN) and their connection with hearing loss".Chinese Journal of Medical Genetics 34.1(2017):128-132.