HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma

科研成果详情

题名	HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma
作者	Chen, Liping 1; Zhao, Hong2; Yang, Xiaoqin 1; Gao, Jackson Y.3; Cheng, Jilin 4
发表日期	2014
发表期刊	Discovery Medicine 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Hepatitis B virus (HBV) is the major causative agent of chronic hepatitis, hepatic decompensation, liver cirrhosis, and hepatocellular carcinoma (HCC). HBV-related serum markers are widely used in clinical diagnosis and prognosis for HBV infection. Among them, the HBV surface antigen (HBsAg) was once regarded as the sole marker for infection. The serum levels of HBsAg, along with HBV DNA levels, are the most important predictors of the risk of developing HCC. Higher levels of HBsAg are usually connected with a higher risk and lower levels of HBsAg are usually connected with a lower risk. However, negative results for serum HBsAg tests do not always represent a clearance or inactivating status of HBV viruses. HCC could still develop in the absence of detectable HBsAg in serum. This situation is called occult hepatitis B virus infection (OBI). OBI is characterized by the presence of HBV viral genome in the patient's liver but no virus surface antigen (HBsAg) detected in serum by commonly used immunoassays. Although there may not be much difference in the extent of HBV genome replication in OBI (HBsAg negative) and the overt HBV infections (HBsAg positive), the duration of HBV replication and its pathological consequences last much longer in OBI than in overt infections. This paper provides a comprehensive review on the reasons behind OBI, the clinical impact of OBI on the development of HCC, and the urgency for implementing new methodological techniques for detecting OBI.
出版者	Solariz, Inc.ops@solariz.info
ISSN	1539-6509
EISSN	1944-7930
卷号	18 期号:99 页码:189-193
收录类别	SCOPUS
URL	查看原文
Pubmed记录号	25336032
Scopus记录号	2-s2.0-84940490117
通讯作者地址	[Cheng, Jilin]Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China
scopus学科分类	Medicine (all)
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/98229
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_消化内科
通讯作者	Cheng, Jilin
作者单位	1.Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China; 2.Department of Gastroenterology, Wenzhou Medical College,Wenzhou,China; 3.Albert Einstein College of Medicine,New York,10461,United States; 4.Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China
推荐引用方式 GB/T 7714	Chen, Liping,Zhao, Hong,Yang, Xiaoqin,et al. HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma[J]. Discovery Medicine,2014,18(99):189-193.
APA	Chen, Liping, Zhao, Hong, Yang, Xiaoqin, Gao, Jackson Y., & Cheng, Jilin. (2014). HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma. Discovery Medicine, 18(99), 189-193.
MLA	Chen, Liping,et al."HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma".Discovery Medicine 18.99(2014):189-193.