题名 | HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma |
作者 | |
发表日期 | 2014 |
发表期刊 | Discovery Medicine 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
摘要 | Hepatitis B virus (HBV) is the major causative agent of chronic hepatitis, hepatic decompensation, liver cirrhosis, and hepatocellular carcinoma (HCC). HBV-related serum markers are widely used in clinical diagnosis and prognosis for HBV infection. Among them, the HBV surface antigen (HBsAg) was once regarded as the sole marker for infection. The serum levels of HBsAg, along with HBV DNA levels, are the most important predictors of the risk of developing HCC. Higher levels of HBsAg are usually connected with a higher risk and lower levels of HBsAg are usually connected with a lower risk. However, negative results for serum HBsAg tests do not always represent a clearance or inactivating status of HBV viruses. HCC could still develop in the absence of detectable HBsAg in serum. This situation is called occult hepatitis B virus infection (OBI). OBI is characterized by the presence of HBV viral genome in the patient's liver but no virus surface antigen (HBsAg) detected in serum by commonly used immunoassays. Although there may not be much difference in the extent of HBV genome replication in OBI (HBsAg negative) and the overt HBV infections (HBsAg positive), the duration of HBV replication and its pathological consequences last much longer in OBI than in overt infections. This paper provides a comprehensive review on the reasons behind OBI, the clinical impact of OBI on the development of HCC, and the urgency for implementing new methodological techniques for detecting OBI. |
出版者 | Solariz, Inc.ops@solariz.info |
ISSN | 1539-6509 |
EISSN | 1944-7930 |
卷号 | 18期号:99页码:189-193 |
收录类别 | SCOPUS |
URL | 查看原文 |
Pubmed记录号 | 25336032 |
Scopus记录号 | 2-s2.0-84940490117 |
通讯作者地址 | [Cheng, Jilin]Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China |
scopus学科分类 | Medicine (all) |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/98229 |
专题 | 第一临床医学院(信息与工程学院)、附属第一医院_内科学_消化内科 |
通讯作者 | Cheng, Jilin |
作者单位 | 1.Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China; 2.Department of Gastroenterology, Wenzhou Medical College,Wenzhou,China; 3.Albert Einstein College of Medicine,New York,10461,United States; 4.Department of Gastroenterology, Shanghai Public Health Clinical Center, Fudan University,Shanghai,China |
推荐引用方式 GB/T 7714 | Chen, Liping,Zhao, Hong,Yang, Xiaoqin,et al. HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma[J]. Discovery Medicine,2014,18(99):189-193. |
APA | Chen, Liping, Zhao, Hong, Yang, Xiaoqin, Gao, Jackson Y., & Cheng, Jilin. (2014). HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma. Discovery Medicine, 18(99), 189-193. |
MLA | Chen, Liping,et al."HBsAg-negative hepatitis B virus infection and hepatocellular carcinoma".Discovery Medicine 18.99(2014):189-193. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论