Toxicity Evaluation of beta-diketone Antibiotics on the Development of Embryo-larval Zebrafish (Danio rerio)

doi:10.1002/tox.21843

科研成果详情

题名	Toxicity Evaluation of beta-diketone Antibiotics on the Development of Embryo-larval Zebrafish (Danio rerio)
作者	Wang, Huili 1; Che, Baoguang 2; Duan, Ailian 2; Mao, Jingwen 2; Dahlgren, Randy A.2; Zhang, Minghua2; Zhang, Hongqin1; Zeng, Aibing 1; Wang, Xuedong 2
发表日期	2014-10
发表期刊	ENVIRONMENTAL TOXICOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	diketone antibiotics zebrafish malformation locomotor behavior antioxidant enzyme
其他关键词	WASTE-WATER ; FLUOROQUINOLONE ANTIBIOTICS ; LIQUID-CHROMATOGRAPHY ; DEGRADATION-PRODUCTS ; MASS-SPECTROMETRY ; PHARMACEUTICALS ; EXPOSURE ; GLUTATHIONE ; EXTRACTION ; BDE-209
摘要	This study evaluated the effects of beta-diketone antibiotics (DKAs) on the development of embryo-larval zebrafish (Danio rerio). When exposure to DKAs, developmental malformations, such as hatching delay, curved body axis, pericardial edema, uninflated swim bladder and yolk sac edema, were observed at 120 h postfertilization (hpf). The estimated 120 hpf nominal concentrations of no observed effect concentration and lowest observed effect concentration for DKAs were 18.75 and 37.50 mg/L, respectively, suggesting that DKAs have much lower toxicity than other persistent pollutants. Following DKA exposure, embryonic heart rates were significantly reduced as compared to the controls at 48 and 60 hpf. The peak bending motion frequency appeared 1 h earlier than in control embryos. The 2.34 and 9.38-mg/L treatment groups had a higher basal swim rate than control groups at 120 hpf in both light and light-to-dark photoperiod experiments. The occurrence of high speed swim rates was enhanced approximately threefold to sevenfold in the 2.34 and 9.38 mg/L treatments compared to the control. Glutathione (GSH) concentrations in the 2.34 and 9.38-mg/L treatments were significantly higher than the control at 72 hpf, suggesting that GSH production was induced at the end of the hatching period. When exposed to DKAs, zebrafish superoxide dismutase enzyme (SOD) activities were significantly inhibited in the early embryonic period, demonstrating that the clearing ability in zebrafish was lower than the generation rate of free radicals. In summary, the combined DKAs were developmentally toxic to zebrafish in their early life stages and had the ability to impair individual behaviors that are of great importance in the assessment of their ecological fitness. (C) 2013Wiley Periodicals, Inc.
资助项目	Public Benefit Project of Zhejiang Province [2011C23114]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270548, 31071115]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y5100333, Y3110050]; Key Project of Environmental Protection Department of Zhejiang Province [2012B014]
出版者	WILEY-BLACKWELL
出版地	HOBOKEN
ISSN	1520-4081
EISSN	1522-7278
卷号	29 期号:10 页码:1134-1146
DOI	10.1002/tox.21843
页数	13
WOS类目	Environmental Sciences ; Toxicology ; Water Resources
WOS研究方向	Environmental Sciences & Ecology ; Toxicology ; Water Resources
WOS记录号	WOS:000342928600004
收录类别	SCIE ; EI ; PUBMED ; SCOPUS
EI入藏号	20144800248728
EI主题词	Antibiotics
URL	查看原文
PubMed ID	23364946
SCOPUSEID	2-s2.0-84907873099
通讯作者地址	[Wang, Xuedong]Department of Environmental Science,Wenzhou Medical College,University-Town,Wenzhou, Zhejiang,325035,China
Scopus学科分类	Toxicology;Management, Monitoring, Policy and Law;Health, Toxicology and Mutagenesis
引用统计	被引频次：51[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/954
专题	公共卫生学院_环境科学系
通讯作者	Wang, Xuedong
作者单位	1.Department of Environmental Science,Wenzhou Medical College,University-Town,Wenzhou, Zhejiang,325035,China; 2.Department of Environmental Science,Wenzhou Medical College,University-Town,Wenzhou, Zhejiang,325035,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Wang, Huili,Che, Baoguang,Duan, Ailian,et al. Toxicity Evaluation of beta-diketone Antibiotics on the Development of Embryo-larval Zebrafish (Danio rerio)[J]. ENVIRONMENTAL TOXICOLOGY,2014,29(10):1134-1146.
APA	Wang, Huili., Che, Baoguang., Duan, Ailian., Mao, Jingwen., Dahlgren, Randy A.., ... & Wang, Xuedong. (2014). Toxicity Evaluation of beta-diketone Antibiotics on the Development of Embryo-larval Zebrafish (Danio rerio). ENVIRONMENTAL TOXICOLOGY, 29(10), 1134-1146.
MLA	Wang, Huili,et al."Toxicity Evaluation of beta-diketone Antibiotics on the Development of Embryo-larval Zebrafish (Danio rerio)".ENVIRONMENTAL TOXICOLOGY 29.10(2014):1134-1146.