Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing

doi:10.1021/acsnano.9b07173

科研成果详情

题名	Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing
作者	Xi, Yuewei 1; Ge, Juan 1; Wang, Min 3; Chen, Mi 3; Niu, Wen 3; Cheng, Wei 3; Xue, Yumeng 3,6; Lin, Cai5; Lei, Bo 1,2,3,4
发表日期	2020-03-24
发表期刊	ACS NANO 影响因子和分区
语种	英语
原始文献类型	Article
关键词	silica-based biomaterials citric-acid-based polymers multifunctional nanofibrous scaffolds tumor therapy wound healing
其他关键词	SKIN-CANCER ; CURCUMIN ; NANOPARTICLES ; MATRIX ; POLYDOPAMINE ; NANOSHELLS ; ELASTOMERS ; SCAFFOLDS ; HYDROGEL ; BACTERIA
摘要	Traditional skin tumor surgery and chronic bacterial-infection-induced wound healing/skin regeneration is still a challenge. The ideal strategy should eliminate the tumor, enhance wound healing/skin formation, and be anti-infection. Herein, we designed a multifunctional elastomeric poly(L-lactic acid)-poly(citrate siloxane)-curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. The PPCP matrix showed intrinsically multifunctional properties including antioxidative, anti-inflammatory, photothermal, antibacterial, anticancer, and angiogenesis bioactivities. The polydopamine/curcumin presented an excellent near-infrared photothermal/cancer cell toxicity capacity, respectively, which supported PPCP for synergetic skin tumor therapy and antibacterial properties in vitro/in vivo. Additionally, the PPCP nanofibrous matrix significantly promotes the adhesion and proliferation of normal skin cells and accelerates the cutaneous wound healing in normal mice and bacterial-infected mice by enhancing the early angiogenesis. The PPCP nanofibrous matrix with multifunctional bioactivities provides a competitive strategy for skin tumor and bacterial-infection-induced wound healing.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51872224]; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KFKT004]; Special Guidance Funds for the Construction of World-class Universities; Characteristic Development in Central Universities [PY3A078]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [xzy022019050]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	1936-0851
EISSN	1936-086X
卷号	14 期号:3 页码:2904-2916
DOI	10.1021/acsnano.9b07173
页数	13
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000526301400028
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20201508395391
EI主题词	Tumors
URL	查看原文
PubMed ID	32031782
SCOPUSEID	2-s2.0-85082342577
ESI高被引论文	2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09
自科自定义期刊分类	T3(B)类
通讯作者地址	[Lei, Bo]National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710000,China
Scopus学科分类	Materials Science (all);Engineering (all);Physics and Astronomy (all)
引用统计	被引频次：141[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8852
专题	附属第一医院_烧伤科
通讯作者	Lei, Bo
作者单位	1.National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710000,China; 2.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi'an Jiaotong University,Xi'an,710049,China; 3.Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an,710049,China; 4.Instrumental Analysis Center,Xi'an Jiaotong University,Xi'an,710049,China; 5.Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 6.Department of Bioengineering,Department of Chemical and Biomolecular Engineering,Henry Samueli School of Engineering and Applied Sciences,University of California at Los Angeles,Los Angeles,90095,United States
推荐引用方式 GB/T 7714	Xi, Yuewei,Ge, Juan,Wang, Min,et al. Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing[J]. ACS NANO,2020,14(3):2904-2916.
APA	Xi, Yuewei., Ge, Juan., Wang, Min., Chen, Mi., Niu, Wen., ... & Lei, Bo. (2020). Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing. ACS NANO, 14(3), 2904-2916.
MLA	Xi, Yuewei,et al."Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing".ACS NANO 14.3(2020):2904-2916.