A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch

doi:10.1007/s10495-018-1499-y

科研成果详情

题名	A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch
作者	Chen, Liping 1; Weng, Bixia1,2; Li, Huimin1,3; Wang, Haonan1; Li, Qian 1; Wei, Xiaoyan 1,4; Deng, Hui 3; Wang, Sicen 5; Jiang, Chengxi 1; Lin, Renyu1,6; Wu, Jianzhang1
发表日期	2019-02
发表期刊	APOPTOSIS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Anti-lung cancer Toxicity Apoptosis Pyroptosis NF-kappa B
其他关键词	MONO-CARBONYL ANALOGS ; DEPENDENT APOPTOSIS ; CURCUMIN ; CHEMOTHERAPY ; MECHANISMS ; SURVIVAL ; ARREST ; DRUGS ; CELLS ; EF24
摘要	Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-B signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.
资助项目	Zhejiang Province Natural Science Fund of China [LY15H280014, LY17H160059, LY19H130001]; Technology Foundation for Medical Science of Zhejiang Province [2015KYA1506]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272462]; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
出版者	SPRINGER
出版地	DORDRECHT
ISSN	1360-8185
EISSN	1573-675X
卷号	24 期号:1-2 页码:74-82
DOI	10.1007/s10495-018-1499-y
页数	9
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000458485200007
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30519834
SCOPUSEID	2-s2.0-85057970268
通讯作者地址	[Lin, Renyu]Department of Otorhinolaryngology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Pharmacology;Pharmaceutical Science;Clinical Biochemistry;Cell Biology;Biochemistry (medical);Cancer Research
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8784
专题	药学院（分析测试中心）_药学系附属第一医院
通讯作者	Lin, Renyu
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Pharmaceutical Sciences,Tonglu First Peoples Hospital,Hangzhou,311500,China; 3.Department of Periodontics,Hospital & School of Stomatology,Wenzhou Medical University,Wenzhou,325035,China; 4.Department of Pharmacy,Zhejiang Cancer Hospital,Hangzhou,310022,China; 5.School of Pharmacy,Xi’an Jiaotong University,Xi’an,710049,China; 6.Department of Otorhinolaryngology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	药学院（分析测试中心）_药学系
通讯作者单位	附属第一医院
第一作者的第一单位	药学院（分析测试中心）_药学系
推荐引用方式 GB/T 7714	Chen, Liping,Weng, Bixia,Li, Huimin,et al. A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch[J]. APOPTOSIS,2019,24(1-2):74-82.
APA	Chen, Liping., Weng, Bixia., Li, Huimin., Wang, Haonan., Li, Qian., ... & Wu, Jianzhang. (2019). A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch. APOPTOSIS, 24(1-2), 74-82.
MLA	Chen, Liping,et al."A thiopyran derivative with low murine toxicity with therapeutic potential on lung cancer acting through a NF-kappa B mediated apoptosis-to-pyroptosis switch".APOPTOSIS 24.1-2(2019):74-82.