Involvement of the PI3K/Akt/NF-kappa B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract

doi:10.1155/2017/9698410

科研成果详情

题名	Involvement of the PI3K/Akt/NF-kappa B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract
作者	Jin, Yuepeng1; Liu, Lewei 2; Chen, Bicheng3; Bai, Yongyu 4; Zhang, Fan 4; Li, Qiang 4; Lv, Chongqing 5; Sun, Hongwei1; Li, Junjian1; Rubby, Sadman 4; Yang, Lihong1; Andersson, Roland 6; Zhou, Mengtao1
发表日期	2017-12-31
发表期刊	BIOMED RESEARCH INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	NF-KAPPA-B ; CHINESE NATURAL MEDICINES ; INFLAMMATORY MEDIATORS ; ORGAN FAILURE ; MEGASTIGMANE GLYCOSIDES ; BIOACTIVE CONSTITUENTS ; ABSOLUTE STRUCTURES ; ACTIVATION ; INHIBITION ; IMPROVES
摘要	Sedum sarmentosum Bunge possesses excellent anti-inflammatory properties and was used in the treatment of inflammatory diseases. The aim of the present study was to investigate the efficiency of Sedum sarmentosum Bunge extract (SSBE) on severe acute pancreatitis-associated (SAP-associated) acute lung injury (ALI) in rats and to explore the underlying mechanisms. Here, we used a sodium taurocholate-induced SAP rat model to determine the role of SSBE in ALI. During the course of pancreatitis, the expressions of phosphorylated phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt) and nuclear factor-kappa B (NF-kappa B) p65 in the lungs were upregulated. Meanwhile, a parallel increase in the levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the lungs was observed after the induction of SAP. Treatment with SSBE significantly reduced the expression of p-Akt and p-p65 in the lungs and attenuated the severity of SAP-associated ALI compared to the SAP group at 12 h and 24 h. In summary, this study showed that SSBE has beneficial effects on SAP-associated ALI, probably through the PI3-K/Akt signaling pathways by suppressing the NF-kappa B activities.
资助项目	China National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81370563]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ13H160022]; Bureau of Chinese Medicine of Zhejiang Province [2011ZA073]; Bureau of Science and Technology of Wenzhou [H20110016]; Excellent Youth Foundation of Zhejiang Provincial Natural Science [LR14H030001]; Ministry of Health of China [WKJ2012-2-033]; Science Technology Department of Zhejiang province [2012C23108]; Public Welfare Technology Application Research Project
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6133
EISSN	2314-6141
卷号	2017 页码:9698410
DOI	10.1155/2017/9698410
页数	13
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS记录号	WOS:000417014300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29359164
PMC记录号	PMC5735615
SCOPUSEID	2-s2.0-85042151672
通讯作者地址	[Zhou, Mengtao]Department of Surgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou, Zhejiang Province,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Immunology and Microbiology (all)
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/8691
专题	附属第一医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_外科实验室
通讯作者	Zhou, Mengtao
作者单位	1.Department of Surgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou, Zhejiang Province,China; 2.YueQing Affiliated Hospital of Wenzhou Medical University,YueQing People's Hospital,Yueqing, Zhejiang Province,China; 3.Zhejiang Provincial Top Key Discipline in Surgery,Wenzhou Key Laboratory of Surgery,Department of Surgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou, Zhejiang Province,China; 4.Wenzhou Medical University,Wenzhou,Zhejiang Province,China; 5.Shengli Oilfield Central Hospital,Dongying,Shandong Province,China; 6.Department of Surgery,Clinical Sciences Lund,Lund University and Lund University Hospital,Sweden
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Jin, Yuepeng,Liu, Lewei,Chen, Bicheng,et al. Involvement of the PI3K/Akt/NF-kappa B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract[J]. BIOMED RESEARCH INTERNATIONAL,2017,2017:9698410.
APA	Jin, Yuepeng., Liu, Lewei., Chen, Bicheng., Bai, Yongyu., Zhang, Fan., ... & Zhou, Mengtao. (2017). Involvement of the PI3K/Akt/NF-kappa B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract. BIOMED RESEARCH INTERNATIONAL, 2017, 9698410.
MLA	Jin, Yuepeng,et al."Involvement of the PI3K/Akt/NF-kappa B Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract".BIOMED RESEARCH INTERNATIONAL 2017(2017):9698410.