| 题名 | The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration |
| 作者 | |
| 发表日期 | 2022-09 |
| 发表期刊 | AGING AND DISEASE 影响因子和分区 |
| 语种 | 英语 |
| 原始文献类型 | Article ; Early Access |
| 关键词 | intervertebral disc degeneration (IVDD) Diabetes cytokines |
| 其他关键词 | NUCLEUS PULPOSUS CELLS ; STRESS-INDUCED SENESCENCE ; GLYCATION END-PRODUCTS ; TNF-ALPHA ; NOTOCHORDAL CELLS ; HIGH GLUCOSE ; PROINFLAMMATORY CYTOKINES ; INTERLEUKIN-6 IL-6 ; GROWTH-FACTOR ; APOPTOSIS |
| 摘要 | Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Diabetes mellitus is a chronic inflammatory disease that may cause or aggravate IVDD; however, the mechanism by which diabetes induce IVDD is currently unclear. Compared to non-diabetic individuals, diabetic patients have higher levels of plasma cytokines, especially TNF-alpha, IL-10, IL-5, IL-6, IL-7, IL-10, and IL-18. Due to the crucial role of cytokines in the process of intervertebral disc degeneration, we hypothesized that elevation of these cytokines in plasma of diabetic patients may be involved in the process of diabetes-induced IVDD. In this review, changes in plasma cytokine levels in diabetic patients were summarized and the potential role of elevated cytokines in diabetes induced IVDD was discussed. Results showed that some cytokines such as TNF-alpha and IL-10 may accelerate the development of IVDD, while others such as IL-10 is supposed to prevent its development. Apoptosis, senescence, and extracellular matrix metabolism were found to be regulated by these cytokines in IVDD. Further studies are required to validate the cytokines targeted strategy for diabetic IVDD therapy. |
| 资助项目 | Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LGF21H060011, LGF20H060013]; National Nature Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82172494, 81871806, 81972094]; Zhejiang Provincial Project for Medical and Health Science and Technology [2020KY638, 2020KY190]; Wenzhou Science and Technology Bureau Foundation [ZY2019014, ZY2020059] |
| 出版者 | INT SOC AGING & DISEASE |
| 出版地 | FORT WORTH |
| ISSN | 2152-5250 |
| 卷号 | 13期号:5页码:1323-1335 |
| DOI | 10.14336/AD.2022.0129 |
| 页数 | 13 |
| WOS类目 | Geriatrics & Gerontology |
| WOS研究方向 | Geriatrics & Gerontology |
| WOS记录号 | WOS:000754425100001 |
| 收录类别 | SCIE ; PUBMED ; SCOPUS |
| URL | 查看原文 |
| PubMed ID | 36186138 |
| SCOPUSEID | 2-s2.0-85140077638 |
| 通讯作者地址 | [Wang, Xiangyang]Department of Orthopaedics,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,West Xueyuan Road, Zhejiang,Wenzhou,China ; [Zhang, Xiaolei]Department of Orthopaedics,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,West Xueyuan Road, Zhejiang,Wenzhou,China |
| Scopus学科分类 | Pathology and Forensic Medicine;Geriatrics and Gerontology;Neurology (clinical);Cell Biology |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/8445 |
| 专题 | 第二临床医学院、附属第二医院、育英儿童医院 附属第二医院 第二临床医学院、附属第二医院、育英儿童医院_外科学 |
| 通讯作者 | Wang, Xiangyang; Zhang, Xiaolei |
| 作者单位 | 1.Department of Orthopaedics,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Key Laboratory of Orthopaedics of Zhejiang Province,Zhejiang,Wenzhou,China; 3.The Second School of Medicine,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Chinese Orthopaedic Regenerative Medicine Society,Zhejiang,Hangzhou,China; 5.Department of Orthopedic Surgery,The Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,China; 6.Orthopedics Research Institute of Zhejiang University,Zhejiang,Hangzhou,China; 7.Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province,Zhejiang,Hangzhou,China |
| 第一作者单位 | 附属第二医院; 温州医科大学 |
| 通讯作者单位 | 附属第二医院 |
| 第一作者的第一单位 | 附属第二医院 |
| 推荐引用方式 GB/T 7714 | Li, Sunlong,Huang, Chongan,Xiao, Jian,et al. The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration[J]. AGING AND DISEASE,2022,13(5):1323-1335. |
| APA | Li, Sunlong., Huang, Chongan., Xiao, Jian., Wu, Yuhao., Zhang, Zengjie., ... & Zhang, Xiaolei. (2022). The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration. AGING AND DISEASE, 13(5), 1323-1335. |
| MLA | Li, Sunlong,et al."The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration".AGING AND DISEASE 13.5(2022):1323-1335. |
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