Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis

doi:10.1007/s13277-014-1846-8

科研成果详情

题名	Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis
作者	Yang, Yinlong 1,2; Qian, Jinxian 3; Chen, Yizuo4; Pan, Yifei4
发表日期	2014-07
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cancer Circulating miR-21 Prognosis Biomarker Meta-analysis
其他关键词	TUMOR-SUPPRESSOR GENE ; HUMAN SOLID TUMORS ; COLORECTAL-CANCER ; SERUM MICRORNA-21 ; BREAST-CANCER ; PANCREATIC-CANCER ; EXPRESSION ; MIR-21 ; BIOMARKERS ; DIAGNOSIS
摘要	Circulating microRNAs (miRNAs) exhibit altered expression in patients with cancer and could be considered as potential prognostic biomarker of cancer. Here, we performed a meta-analysis to summarize all the results from available studies, aiming to analyze the prognostic role of circulating microRNA-21 (miR-21) in human cancers. Eligible studies were identified from PubMed and EMBASE through multiple search strategies. We extracted and estimated the hazard ratios (HRs) for overall survival (OS), which compared the high and low expression levels of circulating miR-21 in patients with a variety of carcinomas. Pooled HRs and 95 % confidence intervals (CIs) were calculated. Eleven studies with a total of 1,224 patients with various carcinomas were included this meta-analysis. For OS, higher circulating miR-21expression could significantly predict worse outcome with the pooled HR of 2.11 (95 % CI 1.36-3.26, P = 0.0009). The subgroup analysis suggested that the elevated circulating miR-21 expression was correlated with worse OS in Asian population with the pooled HR of 2.36 (95 % CI 1.61-3.48, P < 0.0001) and digestive system cancers with the pooled HR of 2.19 (95 % CI 1.01-4.75, P = 0.05). The present meta-analysis suggests that circulating miR-21 expression is associated with poor survival in patients with cancer and could be a prognostic biomarker for those patients.
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	1010-4283
EISSN	1423-0380
卷号	35 期号:7 页码:6365-6371
DOI	10.1007/s13277-014-1846-8
页数	7
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000339736300029
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	24664585
SCOPUSEID	2-s2.0-84904990368
通讯作者地址	[Yang, Yinlong]Department of Breast Surgery,Fudan University Shanghai Cancer Center,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7961
专题	附属第一医院_肿瘤外科第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Yang, Yinlong
作者单位	1.Department of Breast Surgery,Fudan University Shanghai Cancer Center,China; 2.Department of Oncology,Shanghai Medical College,Fudan University,China; 3.Department of Breast Surgery,Kunming Medical University,China; 4.Department of Surgical Oncology,Wenzhou Medical University,China
推荐引用方式 GB/T 7714	Yang, Yinlong,Qian, Jinxian,Chen, Yizuo,et al. Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis[J]. TUMOR BIOLOGY,2014,35(7):6365-6371.
APA	Yang, Yinlong, Qian, Jinxian, Chen, Yizuo, & Pan, Yifei. (2014). Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis. TUMOR BIOLOGY, 35(7), 6365-6371.
MLA	Yang, Yinlong,et al."Prognostic role of circulating microRNA-21 in cancers: evidence from a meta-analysis".TUMOR BIOLOGY 35.7(2014):6365-6371.