科研成果详情

题名Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
作者
发表日期2017-12-31
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES   影响因子和分区
语种英语
原始文献类型Article
关键词diabetic peripheral neuropathy (DPN) schwann cells (SCs) basic fibroblast growth factor (bFGF) nerve growth factor (NGF) coacervate
其他关键词ENDOPLASMIC-RETICULUM STRESS ; NERVE GROWTH-FACTOR ; HEPARIN-BASED COACERVATE ; PROLIFERATION ; REGENERATION ; RATS ; PATHOGENESIS ; INDUCTION ; MELLITUS ; AXONS
摘要Diabetic neuropathy is a kind of insidious complications that impairs neural and vascular function and ultimately leads to somatic and visceral denervation. Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) are important neurotrophic factors for stimulating angiogenesis and improving peripheral nerve function. Administrating a single factor has good therapeutic effect on diabetic peripheral neuropathy (DPN). However, the short half-life and rapid diffusion of growth factors under physiological conditions limits its clinical applications. Here, we used a biodegradable coacervate, composed of heparin and polycation, to dominate the combined release of bFGF and NGF in a steady fashion. We found this combined growth factors (GFs) coacervate, administered as a single injection, improved motor and sensory functions, restored morphometric structure and decreased apoptosis of Schwann cells in a rat model of prolonged DPN. Similarly the GFs coacervate, as compared with free bFGF and NGF combination, markedly reduced the apoptosis level of a rat Schwann cell line, RSC 96 cells in vitro. We also demonstrated that neuroprotective effects of the GFs coacervate in both rat DPN model and hyperglycemia-induced RSC 96 cell model is likely due to suppression of endocytoplasmic reticulum stress (ERS).
资助项目National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [81372112]; Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ15E030003]; Wenzhou Municipal Science & Technology Bureau of China [Y20140574]
出版者IVYSPRING INT PUBL
出版地LAKE HAVEN
ISSN1449-2288
卷号13期号:5页码:640-651
DOI10.7150/ijbs.18636
页数12
WOS类目Biochemistry & Molecular Biology ; Biology
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS记录号WOS:000401904400009
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID28539836
PMC记录号PMC5441180
SCOPUSEID2-s2.0-85019557104
通讯作者地址[Xiao, Jian]WZMU-JCU Joint Research Group for Stem Cell and Tissue Engineering,Institute of Stem Cell and Tissue Engineering,School of Pharmacy,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类Ecology, Evolution, Behavior and Systematics;Applied Microbiology and Biotechnology;Molecular Biology;Developmental Biology;Cell Biology
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引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/7324
专题口腔医学院、附属口腔医院_干细胞与组织工程研究所
药学院(分析测试中心)
附属第一医院
通讯作者Xiao, Jian
作者单位
1.WZMU-JCU Joint Research Group for Stem Cell and Tissue Engineering,Institute of Stem Cell and Tissue Engineering,School of Pharmacy,Wenzhou Medical University,Wenzhou,325035,China;
2.UQ-WMU Joint Research Group for Regenerative Medicine,Oral Health Centre,University of Queensland,Brisbane,4006,Australia;
3.The Institute of Life Sciences,Wenzhou University,Wenzhou,325035,China;
4.Department of Peripheral Neurosurgery,The First Affiliated Hospital Wenzhou Medical University,Wenzhou,325035,China
第一作者单位药学院(分析测试中心)
通讯作者单位药学院(分析测试中心)
第一作者的第一单位药学院(分析测试中心)
推荐引用方式
GB/T 7714
Li, Rui,Ma, Jianfeng,Wu, Yanqing,et al. Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2017,13(5):640-651.
APA Li, Rui., Ma, Jianfeng., Wu, Yanqing., Nangle, Matthew., Zou, Shuang., ... & Xiao, Jian. (2017). Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 13(5), 640-651.
MLA Li, Rui,et al."Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.5(2017):640-651.

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