Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-kappa B activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy

doi:10.1016/j.ejmech.2017.08.022

科研成果详情

题名	Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-kappa B activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy
作者	Qiu, Peihong 1,8; Zhang, Shanshan 1,2; Zhou, Yangyang1,3; Zhu, Min 1; Kang, Yanting 1,3; Chen, Dahui1; Wang, Jiabing 1; Zhou, Peng 4; Li, Wulan1,5; Xu, Qing 6; Jin, Rong3,7; Wu, Jianzhang1,8; Liang, Guang1,8
发表日期	2017-10-20
发表期刊	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	NF-kappa B Gastric cancer Curcuminoid analog Irinotecan
其他关键词	SIGNALING PATHWAYS ; IN-VITRO ; TUMOR-GROWTH ; DEMETHOXYCURCUMIN ; RESISTANCE ; INHIBITION ; APOPTOSIS ; EXPRESSION ; BREAST ; COLON
摘要	NF-kappa B is a critical target for cancer treatment due to its central role in facilitating cancer progression and desensitizing cancer cells to chemotherapeutic drugs. In this study, a series of chemically, modified asymmetric curcuminoid analogs named S01-S15 were synthesized and evaluated for NF-kappa B inhibitory activity in gastric cancer cell lines. Cell growth inhibition assays revealed that most of these analogs effectively inhibited the growth of BGC-823, SGC-7901, and MFC cells. S06 was selected for further research. MIT assay, clonogenic assay, Hoechst 33258 staining assay, and western blotting revealed that S06 could exert anti-gastric cancer effects by downregulating NF-kappa B activity. Moreover, via its effects on NF-kappa B, S06 effectively enhanced the sensitivity of the gastric cancer cells to irinotecan. Together, this study provide a series of new curcuminoid analogs as promising cancer therapeutic agents. (C) 2017 Published by Elsevier Masson SAS.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81402839, 81272462]; Zhejiang Province Natural Science Fund of China [LY17H160059]; Science Research Foundation of National Health and Family Planning Commission of China [WKJ-ZJ-1416]
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
出版地	ISSY-LES-MOULINEAUX
ISSN	0223-5234
EISSN	1768-3254
卷号	139 页码:917-925
DOI	10.1016/j.ejmech.2017.08.022
页数	9
WOS类目	Chemistry, Medicinal
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000412788200070
收录类别	SCIE ; PUBMED ; SCOPUS ; IC
URL	查看原文
Pubmed记录号	28881286
Scopus记录号	2-s2.0-85028732796
自科自定义期刊分类	T3(B)类
通讯作者地址	[Jin, Rong]Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
scopus学科分类	Pharmacology;Drug Discovery;Organic Chemistry
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7321
专题	药学院（分析测试中心）附属第一医院药学院（分析测试中心）_生物有机与药物化学研究中心第一临床医学院（信息与工程学院）、附属第一医院_计算机与信息管理系第一临床医学院（信息与工程学院）、附属第一医院_流行病学第一临床医学院（信息与工程学院）、附属第一医院_内科学_消化内科
通讯作者	Jin, Rong
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Taizhou Traditional Chinese Medicine Hospital,Taizhou,318000,China; 3.Department of Digestive Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,323035,China; 4.Department of Clinical Pharmacy,Taizhou Hospital,Linhai,317000,China; 5.College of Information Science and Computer Engineering,The First Clinical Medical College,Wenzhou Medical University,Wenzhou,325035,China; 6.College of Chemistry and Materials Engineering,Wenzhou University,Wenzhou,325035,China; 7.Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 8.Wenzhou Biomedical Innovation Center,Wenzhou University and Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	生物有机与药物化学研究中心; 温州医科大学
通讯作者单位	生物有机与药物化学研究中心
第一作者的第一单位	生物有机与药物化学研究中心
推荐引用方式 GB/T 7714	Qiu, Peihong,Zhang, Shanshan,Zhou, Yangyang,et al. Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-kappa B activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017,139:917-925.
APA	Qiu, Peihong., Zhang, Shanshan., Zhou, Yangyang., Zhu, Min., Kang, Yanting., ... & Liang, Guang. (2017). Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-kappa B activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 139, 917-925.
MLA	Qiu, Peihong,et al."Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-kappa B activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 139(2017):917-925.