EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells

doi:10.1007/s12264-020-00495-6

科研成果详情

题名	EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells
作者	Gao, Zhen-Zhen 1; Li, Ying-Cong 2; Shao, Chong-Yu 2; Xiao, Jian1; Shen, Ying 2; Zhou, Liang 2,3
发表日期	2020-06
发表期刊	NEUROSCIENCE BULLETIN 影响因子和分区
语种	英语
原始文献类型	Article
关键词	EPAC Proliferation Oligodendrocyte Myelination Transcription factor
其他关键词	ACTIVATION ; PROMOTES ; CAMP ; DIFFERENTIATION ; TRANSCRIPTION ; MTORC1 ; CYCLE ; CNS
摘要	Increasing evidence suggests that a cyclic adenosine monophosphate (cAMP)-dependent intracellular signal drives the process of myelination. Yet, the signal transduction underlying the action of cAMP on central nervous system myelination remains undefined. In the present work, we sought to determine the role of EPAC (exchange protein activated by cAMP), a downstream effector of cAMP, in the development of the myelin sheath using EPAC1 and EPAC2 double-knockout (EPAC(dKO)) mice. The results showed an age-dependent regulatory effect of EPAC1 and EPAC2 on myelin development, as their deficiency caused more myelin sheaths in postnatal early but not late adult mice. Knockout of EPAC promoted the proliferation of oligodendrocyte precursor cells and had diverse effects on myelin-related transcription factors, which in turn increased the expression of myelin-related proteins. These results indicate that EPAC proteins are negative regulators of myelination and may be promising targets for the treatment of myelin-related diseases.
资助项目	National Key Research and Development Program of Ministry of Technology and Science of China [2017YFA0104200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31560273, 81625006, 31571051, 81571098]; Natural Science Foundation of Zhejiang Province, ChinaNatural Science Foundation of Zhejiang Province [Z15C090001]
出版者	SPRINGER
出版地	NEW YORK
ISSN	1673-7067
EISSN	1995-8218
卷号	36 期号:6 页码:639-648
DOI	10.1007/s12264-020-00495-6
页数	10
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000530780000001
收录类别	SCIE ; PUBMED ; SCOPUS ; CSCD
学科领域	医药、卫生
URL	查看原文
CSCD记录号	CSCD:6742398
PubMed ID	32303914
PMC记录号	PMC7270323
SCOPUSEID	2-s2.0-85083855651
通讯作者地址	[Shen, Ying]Department of Neurobiology,Zhejiang University School of Medicine,Hangzhou,310058,China
Scopus学科分类	Neuroscience (all);Physiology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7185
专题	药学院（分析测试中心）_分子药理研究与教学中心
通讯作者	Shen, Ying
作者单位	1.Molecular Pharmacology Research Center,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Neurobiology,Zhejiang University School of Medicine,Hangzhou,310058,China; 3.Key Laboratory of Brain Science,Guizhou Institution of Higher Education,Zunyi Medical University,Zunyi,563000,China
第一作者单位	药学院（分析测试中心）_分子药理研究与教学中心
第一作者的第一单位	药学院（分析测试中心）_分子药理研究与教学中心
推荐引用方式 GB/T 7714	Gao, Zhen-Zhen,Li, Ying-Cong,Shao, Chong-Yu,et al. EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells[J]. NEUROSCIENCE BULLETIN,2020,36(6):639-648.
APA	Gao, Zhen-Zhen, Li, Ying-Cong, Shao, Chong-Yu, Xiao, Jian, Shen, Ying, & Zhou, Liang. (2020). EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells. NEUROSCIENCE BULLETIN, 36(6), 639-648.
MLA	Gao, Zhen-Zhen,et al."EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells".NEUROSCIENCE BULLETIN 36.6(2020):639-648.