| 题名 | Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study |
| 作者 | |
| 发表期刊 | LANCET INFECTIOUS DISEASES 影响因子和分区 |
| 语种 | 英语 |
| 原始文献类型 | Article |
| 其他关键词 | ACUTE RESPIRATORY SYNDROME ; SARS ; PNEUMONIA |
| 摘要 | Background Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. Methods We retrospectively retrieved data for paediatric patients (aged 0-16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. We recorded patients' epidemiological and clinical features. Findings From Jan 17 to March 1, 2020, 36 children (mean age 8.3 [SD 3.5] years) were identified to be infected with severe acute respiratory syndrome coronavirus 2. The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). Of those with fever, four (11%) had a body temperature of 38.5 degrees C or higher, and nine (25%) had a body temperature of 37.5-38.5 degrees C. Typical abnormal laboratory findings were elevated creatine kinase MB (11 [31%]), decreased lymphocytes (11 [31%]), leucopenia (seven [19%]), and elevated procalcitonin (six [17%]). Besides radiographic presentations, variables that were associated significantly with severity of COVID-19 were decreased lymphocytes, elevated body temperature, and high levels of procalcitonin, D-dimer, and creatine kinase MB. All children received interferon alfa by aerosolisation twice a day, 14 (39%) received lopinavir-ritonavir syrup twice a day, and six (17%) needed oxygen inhalation. Mean time in hospital was 14 (SD 3) days. By Feb 28, 2020, all patients were cured. Interpretation Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections. |
| 资助项目 | Ningbo Clinical Research Center for Children's Health and Diseases; Key Scientific and Technological Innovation Projects of Wenzhou; Ningbo Reproductive Medicine Centre |
| 出版者 | ELSEVIER SCI LTD |
| 出版地 | OXFORD |
| ISSN | 1473-3099 |
| EISSN | 1474-4457 |
| 卷号 | 20期号:6页码:689-696 |
| DOI | 10.1016/S1473-3099(20)30198-5 |
| WOS类目 | Infectious Diseases |
| WOS研究方向 | Infectious Diseases |
| WOS记录号 | WOS:000537391000045 |
| 收录类别 | SCIE ; PUBMED ; SCOPUS |
| 发表日期 | 2020-06 |
| URL | 查看原文 |
| Pubmed记录号 | 32220650 |
| PMC记录号 | PMC7158906 |
| Scopus记录号 | 2-s2.0-85083018413 |
| ESI高被引论文 | 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 |
| 自科自定义期刊分类 | T2(A)类 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/7122 |
| 专题 | 其他_附属第三医院（瑞安市人民医院） |
| 通讯作者 | Song, Qifa; Chen, Dong |
| 作者单位 | 1.Ningbo Women & Childrens Hosp, Dept Pediat, Ningbo, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Infect Dis, Affiliated Hosp 3, Wenzhou, Zhejiang, Peoples R China; 3.Ningbo Municipal Ctr Dis Control & Prevent, Dept Microbiol, Ningbo 315010, Zhejiang, Peoples R China; 4.Wenzhou Cent Hosp, Dept Infect Dis, Wenzhou, Zhejiang, Peoples R China; 5.Sixth Peoples Hosp Wenzhou, Wenzhou 325000, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Haiyan,Wu, Junhua,Hong, Liang,et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study[J]. LANCET INFECTIOUS DISEASES,2020,20(6):689-696. |
| APA | Qiu, Haiyan, Wu, Junhua, Hong, Liang, Luo, Yunling, Song, Qifa, & Chen, Dong. (2020). Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. LANCET INFECTIOUS DISEASES, 20(6), 689-696. |
| MLA | Qiu, Haiyan,et al."Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study".LANCET INFECTIOUS DISEASES 20.6(2020):689-696. |
条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Clinical and epidemi（782KB） | 期刊论文 | 开放获取 | CC BY-NC-SA | 浏览 下载 | ||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
学校主页 
图书馆
修改评论