Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study

doi:10.1016/S1473-3099(20)30198-5

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题名	Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study
作者	Qiu, Haiyan 1; Wu, Junhua 1; Hong, Liang2; Luo, Yunling 2; Song, Qifa 3; Chen, Dong 4
发表日期	2020-06
发表期刊	LANCET INFECTIOUS DISEASES 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	ACUTE RESPIRATORY SYNDROME ; SARS ; PNEUMONIA
摘要	Background Since December, 2019, an outbreak of coronavirus disease 2019 (COVID-19) has spread globally. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. Methods We retrospectively retrieved data for paediatric patients (aged 0-16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. We recorded patients' epidemiological and clinical features. Findings From Jan 17 to March 1, 2020, 36 children (mean age 8.3 [SD 3.5] years) were identified to be infected with severe acute respiratory syndrome coronavirus 2. The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). Of those with fever, four (11%) had a body temperature of 38.5 degrees C or higher, and nine (25%) had a body temperature of 37.5-38.5 degrees C. Typical abnormal laboratory findings were elevated creatine kinase MB (11 [31%]), decreased lymphocytes (11 [31%]), leucopenia (seven [19%]), and elevated procalcitonin (six [17%]). Besides radiographic presentations, variables that were associated significantly with severity of COVID-19 were decreased lymphocytes, elevated body temperature, and high levels of procalcitonin, D-dimer, and creatine kinase MB. All children received interferon alfa by aerosolisation twice a day, 14 (39%) received lopinavir-ritonavir syrup twice a day, and six (17%) needed oxygen inhalation. Mean time in hospital was 14 (SD 3) days. By Feb 28, 2020, all patients were cured. Interpretation Although all paediatric patients in our cohort had mild or moderate type of COVID-19, the large proportion of asymptomatic children indicates the difficulty in identifying paediatric patients who do not have clear epidemiological information, leading to a dangerous situation in community-acquired infections.
资助项目	Ningbo Clinical Research Center for Children's Health and Diseases; Key Scientific and Technological Innovation Projects of Wenzhou; Ningbo Reproductive Medicine Centre
出版者	ELSEVIER SCI LTD
出版地	OXFORD
ISSN	1473-3099
EISSN	1474-4457
卷号	20 期号:6 页码:689-696
DOI	10.1016/S1473-3099(20)30198-5
页数	8
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
WOS记录号	WOS:000537391000045
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32220650
PMC记录号	PMC7158906
SCOPUSEID	2-s2.0-85083018413
ESI高被引论文	2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 ; 2024-11
自科自定义期刊分类	T2(A)类
通讯作者地址	[Song, Qifa]Department of Microbiology,Ningbo Municipal Centre for Disease Control and Prevention,Ningbo,315010,China ; [Chen, Dong]Department of Infectious Diseases,Wenzhou Central Hospital and Sixth People's Hospital of Wenzhou,Wenzhou,325000,China
Scopus学科分类	Infectious Diseases
TOP期刊	TOP期刊
引用统计	被引频次：690[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/7122
专题	其他_附属第三医院（瑞安市人民医院）
通讯作者	Song, Qifa; Chen, Dong
作者单位	1.Department of Pediatrics,Ningbo Women and Children's Hospital,Ningbo,China; 2.Department of Infectious Diseases,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Microbiology,Ningbo Municipal Centre for Disease Control and Prevention,Ningbo,China; 4.Department of Infectious Diseases,Wenzhou Central Hospital and Sixth People's Hospital of Wenzhou,Wenzhou,China
推荐引用方式 GB/T 7714	Qiu, Haiyan,Wu, Junhua,Hong, Liang,et al. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study[J]. LANCET INFECTIOUS DISEASES,2020,20(6):689-696.
APA	Qiu, Haiyan, Wu, Junhua, Hong, Liang, Luo, Yunling, Song, Qifa, & Chen, Dong. (2020). Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. LANCET INFECTIOUS DISEASES, 20(6), 689-696.
MLA	Qiu, Haiyan,et al."Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study".LANCET INFECTIOUS DISEASES 20.6(2020):689-696.

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