Biocompatible Graphene Oxide-Based Glucose Biosensors

doi:10.1021/la100886x

科研成果详情

题名	Biocompatible Graphene Oxide-Based Glucose Biosensors
作者	Liu, Yong1; Yu, Dingshan 2; Zeng, Chao 1; Miao, Zongcheng 3; Dai, Liming1,2
发表日期	2010-05-04
发表期刊	LANGMUIR 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Aldehydes Amines Biocompatibility Diagnosis Electrodes Enzyme electrodes Glucose Glucose oxidase Glucose sensors Cell attachments Clinical diagnosis Covalent attachment Glucose biosensor Graphene oxide nanosheets Reproducibilities Retinal pigment epithelium Storage stability
其他关键词	LARGE-AREA ; ELECTRODE ; IMMOBILIZATION ; DIAMOND ; FILMS
摘要	This letter demonstrates that a novel, highly efficient enzyme electrode can be directly obtained using covalent attachment between carboxyl acid groups of graphene oxide sheets and amines of glucose oxidase. The resulting biosensor exhibits a broad linear range up to 28 mM.mm(-2) glucose with a sensitivity of 8.045 mA.cm(-2), M-1. The glucose oxidase-immobilized graphene oxide electrode also shows a reproducibility and a good storage stability, suggesting potentials for a wide range of practical applications. The biocompatibility of as-synthesized graphene oxide nanosheets with human cells, especially retinal pigment epithelium (RPE) cells, was in for the first time in the present work. Microporous graphene oxide exhibits good biocompatibility and has potential advantages with respect to cell attachment and proliferation, leading to opportunities for using graphene-based biosensors for the clinical diagnosis.
资助项目	Zhejiang Department of Education [Y200906587]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2009DFB30380]; Zhejiang Department of Science and Technology [2009C13019]
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	0743-7463
EISSN	1520-5827
卷号	26 期号:9 页码:6158-6160
DOI	10.1021/la100886x
页数	24
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Materials Science
WOS记录号	WOS:000276969700018
收录类别	SCIE ; EI ; PUBMED ; SCOPUS
EI入藏号	20101812910724
EI主题词	Graphene
URL	查看原文
PubMed ID	20349968
SCOPUSEID	2-s2.0-77951686517
ESI高被引论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03
通讯作者地址	[Liu, Yong]Biomedical Engineering Academy,School of Ophthalmology and Optometry,Wenzhou Medical College,270 Xueyuan Road,China
Scopus学科分类	Materials Science (all);Condensed Matter Physics;Surfaces and Interfaces;Spectroscopy;Electrochemistry
引用统计	被引频次：569[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6899
专题	温州医科大学
通讯作者	Liu, Yong
作者单位	1.Biomedical Engineering Academy,School of Ophthalmology and Optometry,Wenzhou Medical College,270 Xueyuan Road,China; 2.Department of Chemical Engineering,Case Western Reserve University,10900 Euclid Avenue,United States; 3.College of Chemistry and Chemical Engineering,Shaan-xi University of Science and Technology,China
推荐引用方式 GB/T 7714	Liu, Yong,Yu, Dingshan,Zeng, Chao,et al. Biocompatible Graphene Oxide-Based Glucose Biosensors[J]. LANGMUIR,2010,26(9):6158-6160.
APA	Liu, Yong, Yu, Dingshan, Zeng, Chao, Miao, Zongcheng, & Dai, Liming. (2010). Biocompatible Graphene Oxide-Based Glucose Biosensors. LANGMUIR, 26(9), 6158-6160.
MLA	Liu, Yong,et al."Biocompatible Graphene Oxide-Based Glucose Biosensors".LANGMUIR 26.9(2010):6158-6160.