Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke

doi:10.1161/01.STR.0000090841.90286.81

科研成果详情

题名	Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke
作者	Fan, Yu Hua 1,3; Zhang, Lei 1,4; Lam, Wynnie W.M.2; Mok, Vincent C.T.1; Wong, Ka Sing 1
发表日期	2003-10
发表期刊	STROKE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	intracerebral hemorrhage magnetic resonance imaging, gradient-echo
其他关键词	T2-ASTERISK-WEIGHTED MRI ; HEMATOMAS
摘要	Background and Purpose-Cerebral microbleeds (MBs) detected by gradient-echo MRI are considered evidence of advanced microangiopathy with potential for further bleeding. The goal of this study was to determine whether the presence of MBs is a risk factor for subsequent intracerebral hemorrhage among patients with acute ischemic stroke. Methods-We prospectively examined patients hospitalized with acute cerebral infarction with gradient-echo T2*-weighted MRI for the presence of MBs. We recorded demographics, medical history, and stroke severity. Patients were then followed up for the development of stroke, other vascular events, and death. Results-One hundred twenty-one consecutive patients with a mean age of 67.96+/-10.97 years were recruited. MBs were present in 43 patients (35.5%). During follow-up of 27.15+/-11.68 months, 16 patients had recurrent stroke. There was no difference between patients with or without MB for the development of ischemic stroke (5 and 6 respectively, P=0.841). However, 4 patients (9.3%) with MBs and 1 patient (1.3%) without an MB had intracerebral hemorrhage during follow-up (P=0.053). Of the 5 patients who developed subsequent intracerebral hemorrhages, 3 were treated with aspirin and 2 with anticoagulation. Two of the intracerebral hemorrhages occurred in the site where asymptomatic MBs were found at baseline. Conclusions-MBs appear to be a risk factor for subsequent intracerebral hemorrhage among patients with ischemic stroke in this small cohort of Chinese stroke patients. A large cohort study is required to confirm this observation.
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0039-2499
卷号	34 期号:10 页码:2459-2462
DOI	10.1161/01.STR.0000090841.90286.81
页数	4
WOS类目	Clinical Neurology ; Peripheral Vascular Disease
WOS研究方向	Neurosciences & Neurology ; Cardiovascular System & Cardiology
WOS记录号	WOS:000185679100049
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	12958325
SCOPUSEID	2-s2.0-0141530969
通讯作者地址	[Wong, Ka Sing]Dept. of Medicine and Therapeutics,Chinese University of Hong Kong,Hong Kong
Scopus学科分类	Neurology (clinical);Cardiology and Cardiovascular Medicine;Advanced and Specialized Nursing
TOP期刊	TOP期刊
引用统计	被引频次：191[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6766
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院
通讯作者	Wong, Ka Sing
作者单位	1.Dept. of Medicine and Therapeutics,Chinese University of Hong Kong,Hong Kong; 2.Dept. of Radiology and Organ Imaging,Chinese University of Hong Kong,Hong Kong; 3.Department of Neurology,First Affil. Hosp. Sun Yat-Sen Univ.,China; 4.Department of Neurology,First Affiliated Hospital,Wenzhou Medical College,China
推荐引用方式 GB/T 7714	Fan, Yu Hua,Zhang, Lei,Lam, Wynnie W.M.,et al. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke[J]. STROKE,2003,34(10):2459-2462.
APA	Fan, Yu Hua, Zhang, Lei, Lam, Wynnie W.M., Mok, Vincent C.T., & Wong, Ka Sing. (2003). Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. STROKE, 34(10), 2459-2462.
MLA	Fan, Yu Hua,et al."Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke".STROKE 34.10(2003):2459-2462.