题名 | Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence |
作者 | |
发表期刊 | NATURE REVIEWS CARDIOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Review |
其他关键词 | VENTRICULAR DIASTOLIC DYSFUNCTION ; PRESERVED EJECTION FRACTION ; RAT CARDIAC MYOCYTES ; HIGH-FAT DIET ; NF-KAPPA-B ; INHIBITING NLRP3 INFLAMMASOME ; CARDIOVASCULAR-DISEASE RISK ; TO-MESENCHYMAL TRANSITION ; INCIDENT HEART-FAILURE ; GLYCATION END-PRODUCTS |
摘要 | The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied in the past decade, but effective approaches to prevent and treat this disease are limited. Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism associated with diabetes mellitus, which leads to increased oxidative stress and the activation of multiple inflammatory pathways that mediate cellular and extracellular injury, pathological cardiac remodelling, and diastolic and systolic dysfunction. Preclinical studies in animal models of diabetes have identified multiple intracellular pathways involved in the pathogenesis of diabetic cardiomyopathy and potential cardioprotective strategies to prevent and treat the disease, including antifibrotic agents, anti-inflammatory agents and antioxidants. Some of these interventions have been tested in clinical trials and have shown favourable initial results. In this Review, we discuss the mechanisms underlying the development of diabetic cardiomyopathy and heart failure in type 1 and type 2 diabetes mellitus, and we summarize the evidence from preclinical and clinical studies that might provide guidance for the development of targeted strategies. We also highlight some of the novel pharmacological therapeutic strategies for the treatment and prevention of diabetic cardiomyopathy. Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism, increased oxidative stress and activation of pro-inflammatory pathways associated with diabetes mellitus, which can induce cardiac remodelling and dysfunction. In this Review, Tan and colleagues discuss the pathogenesis of diabetic cardiomyopathy and describe signalling pathways that might be potential therapeutic targets. |
资助项目 | NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1R01-HL-125877-01]; American Diabetes AssociationAmerican Diabetes Association [1-15-BS-018, 1-18-IBS-082, 1-13-JF-53]; UofL-China Paediatric Research Exchange Program at the University of Louisville, USA; Norton Children's Hospital Foundation & Norton Healthcare Foundation |
出版者 | NATURE RESEARCH |
出版地 | BERLIN |
ISSN | 1759-5002 |
EISSN | 1759-5010 |
卷号 | 17期号:9页码:585-607 |
DOI | 10.1038/s41569-020-0339-2 |
WOS类目 | Cardiac & Cardiovascular Systems |
WOS研究方向 | Cardiovascular System & Cardiology |
WOS记录号 | WOS:000514761100001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
发表日期 | 2020-09 |
URL | 查看原文 |
Pubmed记录号 | 32080423 |
PMC记录号 | PMC7849055 |
Scopus记录号 | 2-s2.0-85079773506 |
ESI高被引论文 | 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 |
自科自定义期刊分类 | T3(A)类 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/6647 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 |
通讯作者 | Tan, Yi; Cai, Lu |
作者单位 | 1.Univ Louisville, Sch Med, Dept Pediat, Pediat Res Inst, Louisville, KY 40292 USA; 2.Univ Louisville, Norton Childrens Hosp, Wendy Novak Diabet Ctr, Louisville, KY 40292 USA; 3.Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA; 4.First Hosp Jilin Univ, Dept Cardiol, Changchun, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 2, Affiliated Hosp Ctr 2, Chinese Amer Res Inst Diabet Complicat, Wenzhou, Peoples R China; 6.Univ Louisville, Sch Med, Dept Pediat, Div Endocrinol, Louisville, KY 40292 USA; 7.Univ Louisville, Cardiovasc Innovat Inst, Kosair Char Pediat Heart Res Program, Louisville, KY 40292 USA; 8.Univ Louisville, Sch Med, Dept Radiat Oncol, Louisville, KY 40292 USA |
推荐引用方式 GB/T 7714 | Tan, Yi,Zhang, Zhiguo,Zheng, Chao,et al. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence[J]. NATURE REVIEWS CARDIOLOGY,2020,17(9):585-607. |
APA | Tan, Yi, Zhang, Zhiguo, Zheng, Chao, Wintergerst, Kupper A., Keller, Bradley B., & Cai, Lu. (2020). Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. NATURE REVIEWS CARDIOLOGY, 17(9), 585-607. |
MLA | Tan, Yi,et al."Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence".NATURE REVIEWS CARDIOLOGY 17.9(2020):585-607. |
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