Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization

doi:10.1039/c8ra00401c

科研成果详情

题名	Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization
作者	Chen, Anqi 1,2,3; He, Huacheng 3; Ma, Guanglong 4; Li, Yi2; Jiang, Shishuang2; Xuan, Xuan2; Song, Yi 2; Zhang, Cuiyun 2; Xiao, Jian2; Xu, Yunsheng1,2; Wu, Jiang1,2,3; Chen, Shengfu 4
发表日期	2018-12-31
发表期刊	RSC ADVANCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Amino acids Cell proliferation Tissue regeneration Clinical application Degradability Degradative enzymes Glutamic acid Macroscopic and microscopic Re-epithelialization Wound dressings Wound healing effects
其他关键词	DELIVERY ; REPAIR ; PH
摘要	Hydrogels are one of the most promising wound dressings. However, their effectiveness on wound healing is still largely limited due to either the non-degradability or the release of non-therapeutic degradable products. Herein, a biodegradable copolypeptide hydrogel based on the glutamic acid and lysine was synthesized and applied as both wound dressing and therapeutic prodrug. The hydrogel can degrade in the existence of elevated degradative enzymes in a wound environment, which will release therapeutic amino acids to enhance the wound healing. In vivo results found that the hydrogel could effectively promote wound regeneration in both macroscopic and microscopic scales. Further investigation revealed that the wound healing effect of the hydrogel was highly attributed to its enhanced impact on angiogenesis, cell proliferation and re-epithelialization of the wound. All in all, the present study proves that the degradable copolypeptide hydrogel can efficiently improve wound healing and indicates its potent clinical application for wound regeneration.
资助项目	Zhejiang Educational Committee of China [Y201737074]; Wenzhou Science & Technology Bureau of China [Y20170157]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [8160161, 81771531, 81701809, 81571395]
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2046-2069
EISSN	2046-2069
卷号	8 期号:19 页码:10620-10626
DOI	10.1039/c8ra00401c
页数	26
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000428581000030
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20181304937230
EI主题词	Hydrogels
URL	查看原文
PubMed ID	35540456
SCOPUSEID	2-s2.0-85044177021
通讯作者地址	[He, Huacheng]Wenzhou University,Wenzhou,325035,China
Scopus学科分类	Chemistry (all);Chemical Engineering (all)
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6380
专题	附属第一医院研究生工作部（研究生院）
通讯作者	He, Huacheng
作者单位	1.First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China; 2.Wenzhou Medical University,Wenzhou,325035,China; 3.Wenzhou University,Wenzhou,325035,China; 4.Zhejiang University,Hangzhou,310027,China
第一作者单位	附属第一医院; 温州医科大学
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Anqi,He, Huacheng,Ma, Guanglong,et al. Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization[J]. RSC ADVANCES,2018,8(19):10620-10626.
APA	Chen, Anqi., He, Huacheng., Ma, Guanglong., Li, Yi., Jiang, Shishuang., ... & Chen, Shengfu. (2018). Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization. RSC ADVANCES, 8(19), 10620-10626.
MLA	Chen, Anqi,et al."Biodegradable copolypeptide hydrogel prodrug accelerates dermal wound regeneration by enhanced angiogenesis and epithelialization".RSC ADVANCES 8.19(2018):10620-10626.