PPARgamma agonists against respiratory syncytial virus infection in vitro study

科研成果详情

题名	PPARgamma agonists against respiratory syncytial virus infection in vitro study
作者	Chun-Jie Wan; Lin Dong; Jie Lin; Xiao-Fang Chen
发表日期	2011-12-01
发表期刊	Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To search the effect of PPARgamma agonists for infection of RSV in vitro. Methods: The CPE of Hep-2 and A549 cells induced by RSV infection were observed. The effects of 15d-PGJ2 and rosiglitazone on change of CPE of A549 cells induced by RSV infection for 48 h were observed, too. MTT assay was used to detect the rate of viral suppression, and the protective effects of 15d-PGJ2 and rosiglitazone on A549 cells induced by RSV infection for 48 h. Results: A549 cells interfered by 15d-PGJ2 (5 -25 micromol/L) and rosiglitazone (10-50 micromol/L) did not show obvious CPE, MTT assay also showed that the survival rate of A549 cells induced by RSV infection with PPARgamma agonists added, was significantly higher than that of RSV infection without PPARgamma agonists added, the difference was statistically significant (P < 0.01), but comparision between the two drugs showed no statistical significance. The optimal concentrations of 15d-PGJ2 and rosiglitazone were 5 micromol/L and 10 micromol/L respectively. Conclusions: PPARgamma agonist can reduce the CPE of A549 cells after RSV infection and improve the survival rate of A549 cells. PPARgamma agonist can counteract the infection of RSV in A549 cells.
ISSN	1003-9279
卷号	25 期号:6 页码:480-2.
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	22734242
SCOPUSEID	2-s2.0-84864107818
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/63427
专题	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
作者单位	Wenzhou Medical College, Yuying Children's Hospital, Department of Respiratory Medicine, Wenzhou 325027, China.
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_内科学_呼吸内科
推荐引用方式 GB/T 7714	Chun-Jie Wan,Lin Dong,Jie Lin,et al. PPARgamma agonists against respiratory syncytial virus infection in vitro study[J]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology,2011,25(6):480-2..
APA	Chun-Jie Wan, Lin Dong, Jie Lin, & Xiao-Fang Chen. (2011). PPARgamma agonists against respiratory syncytial virus infection in vitro study. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 25(6), 480-2..
MLA	Chun-Jie Wan,et al."PPARgamma agonists against respiratory syncytial virus infection in vitro study".Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 25.6(2011):480-2..