题名 | Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection |
作者 | |
发表日期 | 2005-11-01 |
发表期刊 | Ai zheng = Aizheng = Chinese journal of cancer 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
摘要 | Background & objective: It was proved that nuclear factor kappaB (NF-kappaB) and its inhibitor protein kappaB (I-kappaB) played critical roles in regulating the expression of proapoptotic genes, and NF-kappaB is overexpressed in some tumors and related with tumorigenesis. However, the expression of NF-kappaB and I-kappaB in cervical cancer and its correlation to human papillomavirus (HPV) infection have not been reported yet. This study was to explore the correlation of the expression of NF-kappaB, I-kappaB, and Bcl-2 in cervical cancer to human papillomavirus (HPV) infection. Methods: The expression of NF-kappaB, I-kappaB, and Bcl-2 were detected by immunohistochemistry in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. HPV DNA was detected by polymerase chain reaction (PCR). Results: The positive rates of NF-kappaB and Bcl-2 were significantly higher in cervical cancer than in normal cervical tissue (60.9% vs. 23.1%, 52.2% vs. 0.0%, P < 0.01). The positive rate of I-kappaB was significantly lower in cervical cancer than in normal cervical tissue (30.4% vs. 57.7%, P < 0.05). The expression of NF-kappaB was closely related to Bcl-2 (P < 0.05). The positive rate of NF-kappaB was significantly higher in HPV DNA-positive cervical cancer than in HPV DNA-negative cervical cancer (81.3% vs. 35.7%, P < 0.05), but the positive rates of I-kappaB and Bcl-2 between these 2 groups had no significant difference (P >0.05). Conclusion: The high expression of NF-kappaB and Bcl-2 and the low expression of I-kappaB may be related to cervical carcinogenesis, and NF-kappaB expression may be related to HPV infection. |
卷号 | 24期号:11页码:1350-3. |
收录类别 | PUBMED ; SCOPUS |
URL | 查看原文 |
Pubmed记录号 | 16552961 |
Scopus记录号 | 2-s2.0-36048967920 |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/62937 |
专题 | 基础医学院(机能实验教学中心)_病原生物学与免疫学系 |
作者单位 | Department of Microbiology and Immunology, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, PR China. wyxkd@wzmc.net |
第一作者单位 | 病原生物学与免疫学系 |
第一作者的第一单位 | 病原生物学与免疫学系 |
推荐引用方式 GB/T 7714 | Ke-Dong Xia,Xiang-Min Chen,Qiao-Ai Lin,et al. Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection[J]. Ai zheng = Aizheng = Chinese journal of cancer,2005,24(11):1350-3.. |
APA | Ke-Dong Xia, Xiang-Min Chen, Qiao-Ai Lin, Hai-Yan Dong, Shao Chen, & Li-Fang Zhang. (2005). Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection. Ai zheng = Aizheng = Chinese journal of cancer, 24(11), 1350-3.. |
MLA | Ke-Dong Xia,et al."Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection".Ai zheng = Aizheng = Chinese journal of cancer 24.11(2005):1350-3.. |
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