Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection

科研成果详情

题名	Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection
作者	Ke-Dong Xia; Xiang-Min Chen; Qiao-Ai Lin; Hai-Yan Dong; Shao Chen; Li-Fang Zhang
发表日期	2005-11-01
发表期刊	Ai zheng = Aizheng = Chinese journal of cancer 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Background & objective: It was proved that nuclear factor kappaB (NF-kappaB) and its inhibitor protein kappaB (I-kappaB) played critical roles in regulating the expression of proapoptotic genes, and NF-kappaB is overexpressed in some tumors and related with tumorigenesis. However, the expression of NF-kappaB and I-kappaB in cervical cancer and its correlation to human papillomavirus (HPV) infection have not been reported yet. This study was to explore the correlation of the expression of NF-kappaB, I-kappaB, and Bcl-2 in cervical cancer to human papillomavirus (HPV) infection. Methods: The expression of NF-kappaB, I-kappaB, and Bcl-2 were detected by immunohistochemistry in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. HPV DNA was detected by polymerase chain reaction (PCR). Results: The positive rates of NF-kappaB and Bcl-2 were significantly higher in cervical cancer than in normal cervical tissue (60.9% vs. 23.1%, 52.2% vs. 0.0%, P < 0.01). The positive rate of I-kappaB was significantly lower in cervical cancer than in normal cervical tissue (30.4% vs. 57.7%, P < 0.05). The expression of NF-kappaB was closely related to Bcl-2 (P < 0.05). The positive rate of NF-kappaB was significantly higher in HPV DNA-positive cervical cancer than in HPV DNA-negative cervical cancer (81.3% vs. 35.7%, P < 0.05), but the positive rates of I-kappaB and Bcl-2 between these 2 groups had no significant difference (P >0.05). Conclusion: The high expression of NF-kappaB and Bcl-2 and the low expression of I-kappaB may be related to cervical carcinogenesis, and NF-kappaB expression may be related to HPV infection.
卷号	24 期号:11 页码:1350-3.
收录类别	PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	16552961
Scopus记录号	2-s2.0-36048967920
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62937
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系
作者单位	Department of Microbiology and Immunology, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, PR China. wyxkd@wzmc.net
第一作者单位	病原生物学与免疫学系
第一作者的第一单位	病原生物学与免疫学系
推荐引用方式 GB/T 7714	Ke-Dong Xia,Xiang-Min Chen,Qiao-Ai Lin,et al. Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection[J]. Ai zheng = Aizheng = Chinese journal of cancer,2005,24(11):1350-3..
APA	Ke-Dong Xia, Xiang-Min Chen, Qiao-Ai Lin, Hai-Yan Dong, Shao Chen, & Li-Fang Zhang. (2005). Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection. Ai zheng = Aizheng = Chinese journal of cancer, 24(11), 1350-3..
MLA	Ke-Dong Xia,et al."Correlation of expression of nuclear factor kappaB, inhibitor protein kappaB, and Bcl-2 in cervical cancer to human papillomavirus infection".Ai zheng = Aizheng = Chinese journal of cancer 24.11(2005):1350-3..