Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats

doi:10.3736/jcim20040212

科研成果详情

题名	Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats
作者	Sun-Zhong Mao; Zhe Yan; Yu-Peng Xie
发表日期	2004-03-01
发表期刊	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 影响因子和分区
语种	英语
原始文献类型	Article
摘要	Objective: To study the preventive effect of Breviscapus Injection on the chronic hypoxic myocardium injury in rats and its mechanism. Methods: Transmission electron microscope and biochemical analysis were used to assay the therapeutic effect of Breviscapus Injection in rat model induced by 4 week's hypoxia. Results: The contents of malondialdehyde (MDA) and Ca(2+) in the homogenate of myocardial tissue of the hypoxic rats were significantly higher than those of the control rats. The activities of superoxide dismutase (SOD), nitric oxide synthase (NOS) in the homogenate of myocardial tissue and the plasmic NO levels of the hypoxic rats were significantly lower than those of the control rats. Breviscapus Injection reduced the contents of MDA and Ca(2+), and increased the levels of SOD, NOS and NO. Ultrastructural examination revealed that the injuries of the ultrastructure of heart in hypoxic rats were improved by treatment with Breviscapus Injection. Conclusion: Breviscapus Injection can effectively prevent and treat the hypoxia-induced myocardial damage. One of its mechanisms may relate to its adjusting NO level, anti-damaging of free radicals and inhibiting calcium overload.
ISSN	1672-1977
卷号	2 期号:2 页码:117-9.
DOI	10.3736/jcim20040212
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	15339472
SCOPUSEID	2-s2.0-7944233578
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/62893
专题	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
作者单位	Department of Biochemistry, Wenzhou Medical College, Wenzhou, Zhejiang Province 325027, China. lmao@wzmc.com
第一作者单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
第一作者的第一单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
推荐引用方式 GB/T 7714	Sun-Zhong Mao,Zhe Yan,Yu-Peng Xie. Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats[J]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine,2004,2(2):117-9..
APA	Sun-Zhong Mao, Zhe Yan, & Yu-Peng Xie. (2004). Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2(2), 117-9..
MLA	Sun-Zhong Mao,et al."Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats".Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2.2(2004):117-9..

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