题名 | Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells |
作者 | |
发表日期 | 2015-12-31 |
发表期刊 | MEDIATORS OF INFLAMMATION 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | GROWTH-FACTOR ; KAPPA-B ; CARCINOMA ; COX-2 ; INOS ; CARCINOGENESIS ; ACTIVATION ; CYTOKINES ; SURVIVAL ; MOUSE |
摘要 | Enhanced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) is associated with the pathogenic processes of various tumor types. COX-2 and iNOS expression in the immunomodulatory dendritic cells is mediated by the granulocyte macrophage-colony stimulating factor (GM-CSF), which is also expressed by cervical cancer cells; however, whether and how GM-CSF regulates COX-2 and iNOS expression in clinical cervical cancer cells remain unknown. In this study, we found that the COX-2 and iNOS expression was upregulated in the cervical cancer tissues and positively correlated with cancer metastasis and stage. About one-half of the cervical cancer tissues showed strong/moderate GM-CSF expression, while the normal cervical tissues showed >80% positive rate; no GM-CSFR protein was detectable on the cervical cancer cells. The GM-CSF expression was negatively correlated with the COX-2 and iNOS expression in the cervical cancer tissues and the functional negative regulatory effect of GM-CSF on COX-2/iNOS expression was demonstrated in various cervical cancer cell lines. Therefore, in cervical cancer cells, GM-CSF might contribute an antitumor response by inhibiting iNOS and COX-2 expression in a GM-CSFR independent manner. |
资助项目 | General Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371748, 81373075] |
出版者 | HINDAWI LTD |
出版地 | LONDON |
ISSN | 0962-9351 |
EISSN | 1466-1861 |
卷号 | 2015页码:601604 |
DOI | 10.1155/2015/601604 |
页数 | 10 |
WOS类目 | Cell Biology ; Immunology |
WOS研究方向 | Cell Biology ; Immunology |
WOS记录号 | WOS:000358619500001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 26257474 |
PMC记录号 | PMC4518190 |
SCOPUSEID | 2-s2.0-84938150183 |
通讯作者地址 | [Ou, Rongying]Department of Gynecology and Obstetrics, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China |
Scopus学科分类 | Immunology;Cell Biology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/6253 |
专题 | 附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院_皮肤病与性病学 |
通讯作者 | Ou, Rongying |
作者单位 | 1.Department of Dermatovenerology, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Institute of Dermatovenerology, Wenzhou Medical University,Wenzhou,325000,China; 3.Jingmen First People's Hospital,Hubei,448000,China; 4.Institute of Immunology, PLA, Third Military Medical University,Chongqing,400038,China; 5.Department of Dermatology,105th Hospital of PLA,Hefei,230001,China; 6.Department of Gynecology and Obstetrics, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China |
第一作者单位 | 附属第一医院; 温州医科大学 |
通讯作者单位 | 附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Jiang, Nanyan,Tian, Zhiqiang,Tang, Jun,et al. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells[J]. MEDIATORS OF INFLAMMATION,2015,2015:601604. |
APA | Jiang, Nanyan, Tian, Zhiqiang, Tang, Jun, Ou, Rongying, & Xu, Yunsheng. (2015). Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells. MEDIATORS OF INFLAMMATION, 2015, 601604. |
MLA | Jiang, Nanyan,et al."Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells".MEDIATORS OF INFLAMMATION 2015(2015):601604. |
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