Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells

doi:10.1155/2015/601604

科研成果详情

题名	Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells
作者	Jiang, Nanyan 1,2,3; Tian, Zhiqiang 4; Tang, Jun 5; Ou, Rongying6; Xu, Yunsheng1,2
发表日期	2015-12-31
发表期刊	MEDIATORS OF INFLAMMATION 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	GROWTH-FACTOR ; KAPPA-B ; CARCINOMA ; COX-2 ; INOS ; CARCINOGENESIS ; ACTIVATION ; CYTOKINES ; SURVIVAL ; MOUSE
摘要	Enhanced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) is associated with the pathogenic processes of various tumor types. COX-2 and iNOS expression in the immunomodulatory dendritic cells is mediated by the granulocyte macrophage-colony stimulating factor (GM-CSF), which is also expressed by cervical cancer cells; however, whether and how GM-CSF regulates COX-2 and iNOS expression in clinical cervical cancer cells remain unknown. In this study, we found that the COX-2 and iNOS expression was upregulated in the cervical cancer tissues and positively correlated with cancer metastasis and stage. About one-half of the cervical cancer tissues showed strong/moderate GM-CSF expression, while the normal cervical tissues showed >80% positive rate; no GM-CSFR protein was detectable on the cervical cancer cells. The GM-CSF expression was negatively correlated with the COX-2 and iNOS expression in the cervical cancer tissues and the functional negative regulatory effect of GM-CSF on COX-2/iNOS expression was demonstrated in various cervical cancer cell lines. Therefore, in cervical cancer cells, GM-CSF might contribute an antitumor response by inhibiting iNOS and COX-2 expression in a GM-CSFR independent manner.
资助项目	General Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371748, 81373075]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	0962-9351
EISSN	1466-1861
卷号	2015 页码:601604
DOI	10.1155/2015/601604
页数	10
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:000358619500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26257474
PMC记录号	PMC4518190
SCOPUSEID	2-s2.0-84938150183
通讯作者地址	[Ou, Rongying]Department of Gynecology and Obstetrics, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Immunology;Cell Biology
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/6253
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_皮肤病与性病学
通讯作者	Ou, Rongying
作者单位	1.Department of Dermatovenerology, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Institute of Dermatovenerology, Wenzhou Medical University,Wenzhou,325000,China; 3.Jingmen First People's Hospital,Hubei,448000,China; 4.Institute of Immunology, PLA, Third Military Medical University,Chongqing,400038,China; 5.Department of Dermatology,105th Hospital of PLA,Hefei,230001,China; 6.Department of Gynecology and Obstetrics, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 温州医科大学
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Jiang, Nanyan,Tian, Zhiqiang,Tang, Jun,et al. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells[J]. MEDIATORS OF INFLAMMATION,2015,2015:601604.
APA	Jiang, Nanyan, Tian, Zhiqiang, Tang, Jun, Ou, Rongying, & Xu, Yunsheng. (2015). Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells. MEDIATORS OF INFLAMMATION, 2015, 601604.
MLA	Jiang, Nanyan,et al."Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells".MEDIATORS OF INFLAMMATION 2015(2015):601604.