题名 | Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients |
作者 | |
发表期刊 | MITOCHONDRION 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Oncocytic tumors Mitochondrial DNA mutations Mitochondrial haplogroup Complex I Heteroplasmy |
其他关键词 | DNA MUTATIONS |
摘要 | Oncocytic tumors are composed of oncocytes characterized by acidophilic granular and reticular cytoplasm. Such features have been attributed to the distinctive aggregation of abnormal mitochondria. Sporadic mitochondrial DNA (mtDNA) mutations, particularly those in complex I subunit genes, have been identified as one of the most noticeable alterations. We reviewed 11,051 cases of patients with thyroid tumors who visited the First Affiliated Hospital of Wenzhou Medical University from January 2011 to August 2017, and we were able to identify 123 cases as oncocytic tumors. We found that older people are at higher risk (P < 0.001) for oncocytic tumors. We confirmed an increased mitochondrial mass in representative samples. Furthermore, a comprehensive analysis of the mitochondrial genomes in patients with oncocytomas revealed 1) haplogroups D5 and A exhibit increased risk of oncocytomas; 2) 60% of mtDNA mutations are in genes encoding respiratory complex subunits while 8% occur in rRNA and 4% in tRNA regions; 3) among mutations in coding regions, 50% are in Complex I genes, including most of the disruptive mutations; 4) 64% of mtDNA mutations are heteroplasmic. Our studies imply a tumorigenesis mechanism for oncocytomas involving mitochondrial alterations mediated by genome instability and modified by mitochondrial haplogroups. |
资助项目 | Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LZ12H12001] |
出版者 | ELSEVIER SCI LTD |
出版地 | OXFORD |
ISSN | 1567-7249 |
EISSN | 1872-8278 |
卷号 | 45页码:1-6 |
DOI | 10.1016/j.mito.2018.01.008 |
WOS类目 | Cell Biology ; Genetics & Heredity |
WOS研究方向 | Cell Biology ; Genetics & Heredity |
WOS记录号 | WOS:000460853300001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
发表日期 | 2019-03 |
URL | 查看原文 |
Pubmed记录号 | 29386142 |
Scopus记录号 | 2-s2.0-85041916606 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/5979 |
专题 | 检验医学院(生命科学学院、生物学实验教学中心) 基础医学院(机能实验教学中心)_病理学与病理生理学系 |
通讯作者 | Chen, Guorong; Lyu, Jianxin; Bai, Yidong |
作者单位 | 1.Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Lab Med, Minist Educ,Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China; 2.Univ Texas San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA; 3.Wenzhou Med Univ, Dept Pathol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China |
第一作者单位 | 检验医学院(生命科学学院、生物学实验教学中心) |
通讯作者单位 | 病理学与病理生理学系; 病理科; 病理学; 病理学; 病理学; 检验医学院(生命科学学院、生物学实验教学中心) |
第一作者的第一单位 | 检验医学院(生命科学学院、生物学实验教学中心); 病理学与病理生理学系; 检验医学院(生命科学学院、生物学实验教学中心); 检验医学院(生命科学学院、生物学实验教学中心) |
推荐引用方式 GB/T 7714 | Lyu, Lihua,Wang, Qiufeng,Song, Shujie,et al. Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients[J]. MITOCHONDRION,2019,45:1-6. |
APA | Lyu, Lihua., Wang, Qiufeng., Song, Shujie., Li, Liyan., Zhou, Huaibin., ... & Bai, Yidong. (2019). Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients. MITOCHONDRION, 45, 1-6. |
MLA | Lyu, Lihua,et al."Oncocytic tumors are marked by enhanced mitochondrial content and mtDNA mutations of complex I in Chinese patients".MITOCHONDRION 45(2019):1-6. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论