科研成果详情

题名Synergistic effects of Lactobacillus rhamnosus culture supernatant and bone marrow mesenchymal stem cells on the development of alcoholic steatohepatitis in mice
作者
发表日期2019
发表期刊American journal of translational research   影响因子和分区
语种英语
原始文献类型Article
关键词Gut microbiota alcoholic liver disease bone marrow mesenchymal stem cells mTOR natural killer-like B cells. natural killer-like B cells
其他关键词AUTOIMMUNE HEPATITIS ; AUTOPHAGY ; MICROBIOTA ; APOPTOSIS ; PATHWAY
摘要The gut microbiota has been shown to play an important role in chronic liver disease. It has been found that both Lactobacillus rhamnosus and its culture supernatant have the potential to mitigate alcoholic steatohepatitis. However, the exact mechanism is still not fully understood. Bone marrow mesenchymal stem cells have immunosuppressive effects with few side effects. The synergistic effect between Lactobacillus rhamnosus culture supernatant and bone marrow mesenchymal stem cells (BMMSCs) deserves further observation. In this study, a mouse model of chronic alcoholic hepatitis was established by eight weeks of Lieber-DeCarli liquid diet feeding; and LGG-s, BMMSCs or a combination of the two were used to explore a new therapeutic method for alcoholic liver disease and to study the mechanism. The results showed that the combined LGG-s and BMMSC treatment might have a synergistic effect and could improve the symptoms of alcoholic hepatitis by regulating inflammation, autophagy and lymphocyte subsets through the PI3k/NF-kB and PI3K/mTOR pathways. With the treatment, the autophagy rate accelerated, and alcohol-induced natural killer B (NKB) cell and follicular helper T (TFH) cell numbers decreased. These findings suggest that the development of alcoholic hepatitis may occur via PI3K/NF-kB and PI3K/mTOR pathway overactivation as well as through NKB and TFH cell imbalances. Moreover, LGG-s and BMMSCs can regulate these factors and alleviate the disease.
资助项目National Natural Science Foundation of China[2017Z-X10202201];
出版者E-CENTURY PUBLISHING CORP
出版地MADISON
ISSN1943-8141
卷号11期号:9页码:5703-5715.
页数13
WOS类目Oncology ; Medicine, Research & Experimental
WOS研究方向Oncology ; Research & Experimental Medicine
WOS记录号WOS:000488232800032
收录类别PUBMED ; SCOPUS ; SCIE
URL查看原文
PubMed ID31632541
PMC记录号PMC6789285
SCOPUSEID2-s2.0-85076973685
通讯作者地址[Wang, Xiao-Dong]Department of Infectious Diseases,Wenzhou Medical University,Hepatology Institute of Wenzhou Medical University,Wenzhou Key Laboratory of Hepatology,Wenzhou,Zhejiang,325000,China
Scopus学科分类Molecular Medicine;Clinical Biochemistry;Cancer Research
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/55925
专题附属第一医院
其他_附属义乌医院(义乌市中心医院)
通讯作者Wang, Xiao-Dong
作者单位
1.Department of Infectious Diseases,Wenzhou Medical University,Hepatology Institute of Wenzhou Medical University,Wenzhou Key Laboratory of Hepatology,Wenzhou,Zhejiang,325000,China;
2.Department of Gastroenterology,First Hospital of Peking University,Beijing,China;
3.Affiliated Yiwu Central Hospital,Wenzhou Medical University,Wenzhou,China;
4.Department of Infectious Diseases and Liver Diseases,Ningbo Medical Center Lihuili Eastern Hospital,Ningbo,315040,China;
5.Department of Infectious Diseases and Liver Diseases,Taipei Medical University Ningbo Medical Center,Ningbo,315040,China
第一作者单位温州医科大学
通讯作者单位温州医科大学
第一作者的第一单位温州医科大学
推荐引用方式
GB/T 7714
Cai, Chao,Chen, Da-Zhi,Ge, Li-Chao,et al. Synergistic effects of Lactobacillus rhamnosus culture supernatant and bone marrow mesenchymal stem cells on the development of alcoholic steatohepatitis in mice[J]. American journal of translational research,2019,11(9):5703-5715..
APA Cai, Chao., Chen, Da-Zhi., Ge, Li-Chao., Chen, Wen-Kai., Ye, Sha-Sha., ... & Chen, Yong-Ping. (2019). Synergistic effects of Lactobacillus rhamnosus culture supernatant and bone marrow mesenchymal stem cells on the development of alcoholic steatohepatitis in mice. American journal of translational research, 11(9), 5703-5715..
MLA Cai, Chao,et al."Synergistic effects of Lactobacillus rhamnosus culture supernatant and bone marrow mesenchymal stem cells on the development of alcoholic steatohepatitis in mice".American journal of translational research 11.9(2019):5703-5715..

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