Quick chronic liver failure-sequential organ failure assessment: an easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients

doi:10.1097/MEG.0000000000000856

科研成果详情

题名	Quick chronic liver failure-sequential organ failure assessment: an easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients
作者	Zhou, Xiao-Dong1; Zhang, Jia-Ying 5; Liu, Wen-Yue2; Wu, Sheng-Jie1; Shi, Ke-Qing3,4; Braddock, Martin 6; Chen, Yong-Ping3,4; Huang, Wei-Jian1; Zheng, Ming-Hua3,4
发表日期	2017-06
发表期刊	EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	chronic liver failure-sequential organ failure assessment critically ill cirrhosis patients model for end-stage liver disease model for end-stage liver disease-Na mortality risk quick chronic liver failure-sequential organ failure assessment UK model for end-stage liver disease
摘要	Background and aim Critically ill cirrhosis patients have an increased risk of morbidity and mortality, even after admission to the ICU. Our objectives were to compare the predictive accuracy of model for end-stage liver disease (MELD), MELD-Na, UK model for end-stage liver disease, and chronic liver failure-sequential organ failure assessment (CLIF-SOFA) by the development and validation of an easy-to-use prognostic model [named quick CLIF-SOFA (qCLIF-SOFA)] for early risk prediction in critically ill patients with cirrhosis. Patients and methods Overall, 1460 patients were extracted from the MIMIC-III database and enrolled in this study at 30-day and 90-day follow-up. qCLIF-SOFA was developed in the established cohort (n = 730) and a performance analysis was completed in the validation cohort (n = 730) using area under the receiver operating characteristic curve. Results were compared with CLIF-SOFA. Results The performance of CLIF-SOFA was significantly better than that of MELD, MELD-Na, and UK model for end-stage liver disease for predicting both 30-day and 90-day mortality (all P < 0.05). qCLIF-SOFA consisted of five independent factors (bilirubin, creatinine, international normalized ratio, mean arterial pressure, and vasopressin) associated with mortality. In the established cohort, CLIF-SOFA and qCLIF-SOFA predicted mortality with area under the receiver operating characteristic curve values of 0.768 versus 0.743 at 30-day, 0.747 versus 0.744 at 90-day, and 0.699 versus 0.706 at 1 year, respectively (all P > 0.05). A similar result was observed in the validation cohort (0.735 vs. 0.734 at 30 days, 0.723 vs. 0.737 at 90 days, and 0.682 vs. 0.700 at 1 year, respectively, all P > 0.05). Conclusion The utility of CLIF-SOFA was further shown to predict mortality for critically ill cirrhosis patients. The novel and simpler qCLIF-SOFA model showed comparable accuracy compared with existing CLIF-SOFA for prognostic prediction. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; Scientific Research Foundation of Wenzhou [Y20160223]; High Level Creative Talents from Department of Public Health in Zhejiang Province; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0954-691X
EISSN	1473-5687
卷号	29 期号:6 页码:698-705
DOI	10.1097/MEG.0000000000000856
页数	8
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000400505500013
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28240612
SCOPUSEID	2-s2.0-85013994893
通讯作者地址	[Zheng, Ming-Hua]Departments of Hepatology,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5525
专题	附属第一医院附属第一医院_感染内科
通讯作者	Zheng, Ming-Hua
作者单位	1.Departments of Cardiovascular Medicine,Heart Center,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Departments of Endocrinology,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Departments of Hepatology,Liver Research Center,First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China; 4.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China; 5.Intensive Care Unit,Zhe Jiang Chinese Medicine and Western Medicine Integrated Hospital,Hangzhou,China; 6.Global Medicines Development,AstraZeneca R and D,Loughborough,United Kingdom
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Xiao-Dong,Zhang, Jia-Ying,Liu, Wen-Yue,et al. Quick chronic liver failure-sequential organ failure assessment: an easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2017,29(6):698-705.
APA	Zhou, Xiao-Dong., Zhang, Jia-Ying., Liu, Wen-Yue., Wu, Sheng-Jie., Shi, Ke-Qing., ... & Zheng, Ming-Hua. (2017). Quick chronic liver failure-sequential organ failure assessment: an easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(6), 698-705.
MLA	Zhou, Xiao-Dong,et al."Quick chronic liver failure-sequential organ failure assessment: an easy-to-use scoring model for predicting mortality risk in critically ill cirrhosis patients".EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 29.6(2017):698-705.