W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappa B signaling pathway

doi:10.1007/s13277-015-4277-2

科研成果详情

题名	W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappa B signaling pathway
作者	Xia, Yiqun1,2; Weng, Bixia2,3; Wang, Zhankun4; Kang, Yanting 1,2; Shi, Lingyi 2; Huang, Guanqun 5; Ying, Shilong 2; Du, Xiaojing1,2; Chen, Qiuxiang1,2; Jin, Rong1,2; Wu, Jianzhang2; Liang, Guang2
发表日期	2016-04
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	W346 Anticancer drug Curcumin Gastric cancer Apoptosis NF-kappa B
其他关键词	MONO-CARBONYL ANALOGS ; CURCUMIN SUPPRESSES PROLIFERATION ; REGULATED GENE-PRODUCTS ; TUMOR-GROWTH ; PANCREATIC-CANCER ; DOWN-REGULATION ; ACTIVATION ; ANGIOGENESIS ; MODULATION ; EXPRESSION
摘要	The therapeutic agent selectively killing cancer cells is urgently needed for gastric cancer treatment. Curcumin has been investigated for its effect on the cancer treatment because of its significant therapeutic potential and safety profile. A synthetic unsymmetry mono-carbonyl compound termed W346 was developed from curcumin. In this study, we investigated the potential antineoplastic effect and mechanism of W346 against human gastric cancer cells. W346 suppressed the proliferation and invasion, blocked cell cycle arrest at G2/M phase, and increased apoptosis in gastric cancer cells, and it presented obviously improved anticancer activity than curcumin. Moreover, W346 effectively inhibited tumor necrosis factor (TNF-alpha)-induced NF-kappa B activation by suppressing IKK phosphorylation, inhibiting I kappa B-alpha degradation, and restraining the accumulation of NF-kappa B subunit p65 nuclear translocation. W346 also affected NF-kappa B-regulated downstream products involved in cycle arrest and apoptosis. In a word, W346 exhibited significantly improved anti-gastric cancer activity over curcumin by targeting NF-kappa B signaling pathway, and it is likely to be a promising starting point for the development of curcumin-based therapeutic agent.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272462]; Zhejiang Province Natural Science Fund of China [LY14H160044, Y13H300005]; Technology Foundation for Medical Science of Zhejiang Province [2012KYA129]
出版者	SPRINGER
出版地	DORDRECHT
ISSN	1010-4283
EISSN	1423-0380
卷号	37 期号:4 页码:4791-4801
DOI	10.1007/s13277-015-4277-2
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000374904500061
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26520440
SCOPUSEID	2-s2.0-84945569562
通讯作者地址	[Jin, Rong]Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Cancer Research
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5229
专题	附属第一医院温州医科大学药学院（分析测试中心）_药学系
通讯作者	Jin, Rong
作者单位	1.Department of Digestive Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 3.Pharmacy Department,Tonglu First People’s Hospital,Hangzhou,311500,China; 4.Institute of Sports Science,Wenzhou Medical University,Wenzhou,325035,China; 5.Department of General Surgery,The fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou,510700,China
第一作者单位	附属第一医院; 药学院（分析测试中心）_药学系
通讯作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xia, Yiqun,Weng, Bixia,Wang, Zhankun,et al. W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappa B signaling pathway[J]. TUMOR BIOLOGY,2016,37(4):4791-4801.
APA	Xia, Yiqun., Weng, Bixia., Wang, Zhankun., Kang, Yanting., Shi, Lingyi., ... & Liang, Guang. (2016). W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappa B signaling pathway. TUMOR BIOLOGY, 37(4), 4791-4801.
MLA	Xia, Yiqun,et al."W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-kappa B signaling pathway".TUMOR BIOLOGY 37.4(2016):4791-4801.