Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke

doi:10.1515/rams-2019-0024

科研成果详情

题名	Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke
作者	Huang, Dongdong4; Wu, Ke 4; Zhang, Ying 4; Ni, Zhihui4; Zhu, Xiaohong4; Zhu, Can 4; Yang, Jianjing1; Zhuge, Qichuan2; Hu, Jiangnan 3
发表日期	2019-04
发表期刊	REVIEWS ON ADVANCED MATERIALS SCIENCE 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Tissue plasminogen activator Drug delivery Nanomaterial Stroke Thrombolysis
其他关键词	BLOOD-BRAIN-BARRIER ; DOSE-ESCALATION ; THROMBOLYSIS ; NANOPARTICLES ; SAFETY ; DRUG ; NEUROPROTECTION ; TENECTEPLASE ; DESMOTEPLASE ; ANGIOGENESIS
摘要	Stroke is an acute cerebrovascular disorder caused by sudden decrease or interruption of blood flow in brain arteries. Deficiency of timely and effective reperfusion of ischemic brain tissue can lead to irreversible brain injury and neurological dysfunction. Currently, recombinant tissue plasminogen activator (rt-PA) is the only appropriate thrombolytic agent which is approved by FDA for patients with acute ischemic stoke. However, due to the limitation of very narrow therapeutic time window and severe intracranial hemorrhagic complication, the outcome of stroke treatment mediated by rt-PA still remains unsatisfactory. Therefore, it is urgent to find new alternative drugs or develop novel drug delivery system to achieve better outcomes. In recent years, with the rapid development of nanotechonology, nanomaterials as a drug delivery system can provide new strategies and methods to carry t-PA specifically to the occlusion site and provide advanced treatment for stroke. In this review, we briefly introduced the physiopathologic mechanisms of thrombolysis and focused on the comparison of the t-PA mediated thrombolysis and t-PA conjugated nanomaterial mediated thrombolysis.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771262]; Zhejiang Health Science and Technology Project [2016RCA022]; Zhejiang Key Research and Development Project [2017C03027]; Sigma Xi [G2017100192773410]
出版者	SCIENDO
出版地	WARSAW
ISSN	1606-5131
EISSN	1605-8127
卷号	58 期号:1 页码:159-170
DOI	10.1515/rams-2019-0024
页数	12
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:000488215200001
收录类别	SCIE ; EI ; SCOPUS
EI入藏号	20194207546880
EI主题词	Tissue
URL	查看原文
SCOPUSEID	2-s2.0-85073210110
通讯作者地址	[Yang, Jianjing]Department of Neuro-surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Materials Science (all);Condensed Matter Physics
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5213
专题	附属第一医院
通讯作者	Yang, Jianjing
作者单位	1.Department of Neuro-surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Pharmacology and Neuroscience,University of North Texas Health Science Center,Fort Worth,76107,United States; 4.Department of Neurosurgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Huang, Dongdong,Wu, Ke,Zhang, Ying,et al. Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke[J]. REVIEWS ON ADVANCED MATERIALS SCIENCE,2019,58(1):159-170.
APA	Huang, Dongdong., Wu, Ke., Zhang, Ying., Ni, Zhihui., Zhu, Xiaohong., ... & Hu, Jiangnan. (2019). Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke. REVIEWS ON ADVANCED MATERIALS SCIENCE, 58(1), 159-170.
MLA	Huang, Dongdong,et al."Recent Advances in Tissue plasminogen activator-based nanothrombolysis for ischemic stroke".REVIEWS ON ADVANCED MATERIALS SCIENCE 58.1(2019):159-170.