Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy

doi:10.2147/IJGM.S354195

科研成果详情

题名	Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy
作者	Liu, Yunqiang 1; Tu, Mengjun2,3; Wang, Lingling 4,5
发表日期	2022
发表期刊	INTERNATIONAL JOURNAL OF GENERAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FOXS1 pan-cancer biological marker M2-like macrophages Treg cells immunosuppressive microenvironment
其他关键词	FORKHEAD ; PROGRESSION
摘要	Purpose: Only a few studies have reported the role of FOXS1, a transcriptional factor, in the tumor development process. In this article, we investigate the function of FOXS1 in distinct neoplastic development and the tumor immune microenvironment (TIME). Patients and Methods: The latent roles of FOXS1 in various tumors were prospected based on TCGA, GTEx, CCLE, GEPIA2, cBioPortal, TIMER, ImmuCellAI databases, GSVA datasets, GSEA datasets, and R packages. The expression difference, gene alteration, clinical characteristics, prognostic values, biological mechanism, potential pathways, tumor microenvironment, and immune cell infiltration related to FOXS1 were appraised. Results: FOXS1 was strongly expressed in pan-cancer, and this gene was associated with low survival rates. FOXS1 was linked to many pathways that are cancer-promoting and immune-related. The expression of this transcriptional factor in cancers was positively related to immune cell infiltration, especially M2-like macrophages and Treg cells. In addition to that, FOXS1 demonstrated a positive relationship with many immune-suppression genes, such as TGFB1 and ARORA2A. Conclusion: Our study identified an oncogenic effect of FOXS1, which may play a vital role as a prognosticative biological marker in pan-cancer. Exorbitant expression of FOXS1 is associated with high TAMs and Treg cells infiltration. These cells have an immunosuppressive function and promote the development of the immunosuppressive tumor microenvironment. The research of FOXS1 provided a potential drug target for tumor immunotherapy.
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-7074
EISSN	1178-7074
卷号	15 页码:2171-2185
DOI	10.2147/IJGM.S354195
页数	15
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000764009900005
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35241932
PMC记录号	PMC8887970
SCOPUSEID	2-s2.0-85125226900
通讯作者地址	[Wang, Lingling]Department of Clinical Laboratory Center of the Second Affiliated Hospital & Yu Ying Children’s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325027,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5193
专题	眼视光学院（生物医学工程学院）、附属眼视光医院检验医学院（生命科学学院、生物学实验教学中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Wang, Lingling
作者单位	1.School of Medical College,Guangdong Medical University,Guang Dong Province,Zhanjiang,524023,China; 2.Eye Hospital and School of Ophthalmology and Optometry,Wenzhou Medical University,Zhejiang Province,Wenzhou,325027,China; 3.National Clinical Research Center for Ocular Diseases,Zhejiang Province,Wenzhou,325027,China; 4.Department of Clinical Laboratory Center of the Second Affiliated Hospital & Yu Ying Children’s Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325027,China; 5.School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China
通讯作者单位	附属第二医院
推荐引用方式 GB/T 7714	Liu, Yunqiang,Tu, Mengjun,Wang, Lingling. Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy[J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE,2022,15:2171-2185.
APA	Liu, Yunqiang, Tu, Mengjun, & Wang, Lingling. (2022). Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 15, 2171-2185.
MLA	Liu, Yunqiang,et al."Pan-Cancer Analysis Predicts FOXS1 as a Key Target in Prognosis and Tumor Immunotherapy".INTERNATIONAL JOURNAL OF GENERAL MEDICINE 15(2022):2171-2185.