题名 | 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究 |
其他题名 | Association between dyslipidemia and 8-OHdG/Cr among a population exposed to chronic arsenic
|
作者 |
|
发表日期 | 2014-07-10
|
发表期刊 | 中华流行病学杂志
影响因子和分区 |
语种 | 中文
|
原始文献类型 | 学术期刊
|
关键词 | 砷暴露
慢性
8-羟基脱氧鸟苷/肌酐
血脂异常
DNA氧化损伤
|
摘要 | 目的探讨慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。方法采用分层整群抽样方法,随机抽取某饮水型高砷暴露地区407名慢性砷暴露者作为调查对象,检测其血脂水平,并据此分为血脂正常组、HDL-C比值异常组、高TC血症组和HDL-C比值异常合并高TC血症组。采集调查对象晨尿,并使用ELISA试剂盒测定其DNA氧化损伤的关键性标志物8-羟基脱氧鸟苷/肌酐(8-OHdG/Cr)水平。采用广义线性回归模型调整相关混杂因素后,分析慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。结果 4组人群8-OHdG/Cr水平M(Q1~Q3)分别为51.43(36.86~68.57)、55.73(39.90~79.94)、58.08(44.94~69.91)和65.28(49.29~92.95)ng/mg,各组间差异有统计学意义(P=0.006)。广义线生回归模型进一步表明,在校正血压、文化程度、暴露年限、BMI、FPG、性别、主动吸烟、被动吸烟、吸烟指数和饮酒等潜在的混杂因素后,HDL-C比值异常合并高TC血症组8-OHdG/Cr水平与血脂水平呈现出显著正相关(P=0.018),且8-OHdG/Cr水平与其血脂异常程度间存在明显的线性趋势(P=0.016)。结论慢性砷暴露人群8-OHdG/Cr水平与其血脂状态间存在显著的关联性,血脂异常程度越严重,其DNA氧化损伤越明显。 |
其他摘要 | Objective To explore the association between dyslipidemia and the level of 8-OHdG/Cr in urine among a population exposed to chronic arsenic. Methods Four hundred and seven subjects were randomly selected in an arsenic-affected area in Inner Mongolia. After blood biochemical examination, all the subjects were divided into 4 groups based on the results of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). The groups consisted of hypercholesterolemia, HDL-C ratio anomaly, combined hypercholesterolemia and HDL-C ratio anomaly, as well as a normal lipid group. Urine samples were collected and 8-OHdG/Cr was measured using the ELISA method. A generalized linear mixed model was used to analyze the association between dyslipidemia and 8-OHdG/Cr. Results The levels of 8-OHdG/Cr as 55.73 (39.90-79.94) ng/mg, 58.08 (44.94-69.91) ng/mg, 65.28 (49.29-92.95)ng/mg and 51.43 (36.86-68.57)ng/mgin the HDL-C ratio anomaly, hypercholesterolemia, combined hypercholesterolemia and HDL-C ratio anomaly groups and the control group, respectively, which showed significant differences on the levels of 8-OHdG/Cr in the four groups (P=0.006). From the linear regression analysis results showed that the 8-OHdG/Cr level incombined hypercholesterolemia and HDL-C ratio anomaly group was higher (4.25± 0.55 ng/mg) than in the control group (3.96 ± 0.55 ng/mg) (P=0.018). After adjusting for important covariates, there was a linear trend between the levels of 8-OHdG/Cr and dyslipidemia (P=0.016). Conclusion Data from our study showed a linear relation between hypercholesterolemia, HDL-C ratio anomaly and the 8-OHdG/Cr level, suggesting that dyslipidemia was associated with oxidative DNA damage among those arsenic-affected people. |
资助项目 | 浙江省自然科学基金(Y2110454);浙江省科技厅项目(2013c33169);温州市科技局项目(H20100025)~~
|
ISSN | 0254-6450
|
卷号 | 35期号:07页码:802-805 |
收录类别 | CNKI
; 维普
; 北大核心
; CSCD
|
学科领域 | 医药、卫生
; 预防医学、卫生学
; 内科学
|
URL | 查看原文
|
CSCD记录号 | CSCD:5191302
|
维普分类号 | R114
|
CN号 | 11-2338/R
|
引用统计 | |
文献类型 | 期刊论文
|
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/51562
|
专题 | 仁济学院_环境与公共卫生学部
|
作者单位 | |
第一作者单位 | 仁济学院_环境与公共卫生学部
|
第一作者的第一单位 | 仁济学院_环境与公共卫生学部
|
推荐引用方式 GB/T 7714 |
杨辉,毛广运,张海洋,等. 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究[J].
中华流行病学杂志,2014,35(07):802-805.
|
APA |
杨辉, 毛广运, 张海洋, 张传武, 邱文婷, & 郭小娟. (2014). 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究. 中华流行病学杂志, 35(07), 802-805.
|
MLA |
杨辉,et al."慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究".中华流行病学杂志 35.07(2014):802-805.
|
修改评论