慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究

科研成果详情

题名	慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究
其他题名	Association between dyslipidemia and 8-OHdG/Cr among a population exposed to chronic arsenic
作者	杨辉; 毛广运; 张海洋; 张传武; 邱文婷; 郭小娟
发表日期	2014-07-10
发表期刊	中华流行病学杂志影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	砷暴露慢性 8-羟基脱氧鸟苷/肌酐血脂异常 DNA氧化损伤
摘要	目的探讨慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。方法采用分层整群抽样方法,随机抽取某饮水型高砷暴露地区407名慢性砷暴露者作为调查对象,检测其血脂水平,并据此分为血脂正常组、HDL-C比值异常组、高TC血症组和HDL-C比值异常合并高TC血症组。采集调查对象晨尿,并使用ELISA试剂盒测定其DNA氧化损伤的关键性标志物8-羟基脱氧鸟苷/肌酐(8-OHdG/Cr)水平。采用广义线性回归模型调整相关混杂因素后,分析慢性砷暴露人群DNA氧化损伤与血脂异常的关联性。结果 4组人群8-OHdG/Cr水平M(Q1~Q3)分别为51.43(36.86~68.57)、55.73(39.90~79.94)、58.08(44.94~69.91)和65.28(49.29~92.95)ng/mg,各组间差异有统计学意义(P=0.006)。广义线生回归模型进一步表明,在校正血压、文化程度、暴露年限、BMI、FPG、性别、主动吸烟、被动吸烟、吸烟指数和饮酒等潜在的混杂因素后,HDL-C比值异常合并高TC血症组8-OHdG/Cr水平与血脂水平呈现出显著正相关(P=0.018),且8-OHdG/Cr水平与其血脂异常程度间存在明显的线性趋势(P=0.016)。结论慢性砷暴露人群8-OHdG/Cr水平与其血脂状态间存在显著的关联性,血脂异常程度越严重,其DNA氧化损伤越明显。
其他摘要	Objective To explore the association between dyslipidemia and the level of 8-OHdG/Cr in urine among a population exposed to chronic arsenic. Methods Four hundred and seven subjects were randomly selected in an arsenic-affected area in Inner Mongolia. After blood biochemical examination, all the subjects were divided into 4 groups based on the results of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). The groups consisted of hypercholesterolemia, HDL-C ratio anomaly, combined hypercholesterolemia and HDL-C ratio anomaly, as well as a normal lipid group. Urine samples were collected and 8-OHdG/Cr was measured using the ELISA method. A generalized linear mixed model was used to analyze the association between dyslipidemia and 8-OHdG/Cr. Results The levels of 8-OHdG/Cr as 55.73 (39.90-79.94) ng/mg, 58.08 (44.94-69.91) ng/mg, 65.28 (49.29-92.95)ng/mg and 51.43 (36.86-68.57)ng/mgin the HDL-C ratio anomaly, hypercholesterolemia, combined hypercholesterolemia and HDL-C ratio anomaly groups and the control group, respectively, which showed significant differences on the levels of 8-OHdG/Cr in the four groups (P=0.006). From the linear regression analysis results showed that the 8-OHdG/Cr level incombined hypercholesterolemia and HDL-C ratio anomaly group was higher (4.25± 0.55 ng/mg) than in the control group (3.96 ± 0.55 ng/mg) (P=0.018). After adjusting for important covariates, there was a linear trend between the levels of 8-OHdG/Cr and dyslipidemia (P=0.016). Conclusion Data from our study showed a linear relation between hypercholesterolemia, HDL-C ratio anomaly and the 8-OHdG/Cr level, suggesting that dyslipidemia was associated with oxidative DNA damage among those arsenic-affected people.
资助项目	浙江省自然科学基金（Y2110454）;浙江省科技厅项目（2013c33169）;温州市科技局项目（H20100025）~~
ISSN	0254-6450
卷号	35 期号:07 页码:802-805
收录类别	CNKI ; 维普 ; 北大核心 ; CSCD
学科领域	医药、卫生 ; 预防医学、卫生学 ; 内科学
URL	查看原文
CSCD记录号	CSCD:5191302
维普分类号	R114
CN号	11-2338/R
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/51562
专题	仁济学院_环境与公共卫生学部
作者单位	温州医科大学环境与公共卫生学院
第一作者单位	仁济学院_环境与公共卫生学部
第一作者的第一单位	仁济学院_环境与公共卫生学部
推荐引用方式 GB/T 7714	杨辉,毛广运,张海洋,等. 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究[J]. 中华流行病学杂志,2014,35(07):802-805.
APA	杨辉, 毛广运, 张海洋, 张传武, 邱文婷, & 郭小娟. (2014). 慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究. 中华流行病学杂志, 35(07), 802-805.
MLA	杨辉,et al."慢性砷暴露人群DNA氧化损伤与血脂异常关联性的研究".中华流行病学杂志 35.07(2014):802-805.