SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia

科研成果详情

题名	SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia
作者	Chen, Xiaohe1; Zhao, Lifen 2; Yu, Tian 3; Zeng, Jue 1; Chen, Ming 1
发表日期	2022
发表期刊	AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Serine peptidase inhibitor Kazal-type 2 acute myeloid leukemia immune cell infiltrate prognosis TCGA GEO prognosis.
其他关键词	SERINE-PROTEASE INHIBITOR ; GENE ; PATHWAY ; CANCER ; CELLS ; PD-1
摘要	Background: Serine peptidase inhibitor Kazal type 2 (SPINK2) has been reported to be involved in certain cancers. We conducted an in-depth investigation on the role and mechanism of SPINK2 in acute myeloid leukemia (AML). Methods: The relationship between SPINK2 expression and AML clinicopathologic characteristics was determined using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. Concomitantly, we used Kaplan-Meier survival analysis, as well as univariate and multivariate regression analyses to evaluate SPINK2 as a prognostic marker of AML. Additionally, we annotated the enrichment and function of SPINK2 using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Sets Enrichment Analysis (GSEA). The CIBERSORT algorithm was used to analyze the relationship between SPINK2 expression and immune infiltration. Results: SPINK2 expression was significantly higher in AML patients compared to healthy individuals (P<0.001). The area under receiver operating characteristic curve in the GSE9476 dataset was 0.660, whereas that in the Genotype-Tissue Expression (GTEx) and TCGA datasets was 0.935. In addition, GSEA also showed that several pathways were enriched in the group with high SPINK2 expression, such as PI3K-AKT signaling, PD-L1 expression, and checkpoint pathways. Analysis of immune infiltration showed that SPINK2 expression was correlated with certain immune infiltrating cells. Cox multivariate analysis revealed that the level of SPINK2 was an independent risk factor for the progression of AML (P<0.001). Moreover, age, M1, M5, M6, and CytoRisk-Poor also affected the progression of AML (P<0.05). The C-index of the nomogram in our internal validation was 0.702. Conclusion: The high expression of SPINK2 in AML suggests that SPINK2 may play an important role in the immune microenvironment and thus could be a biomarker for diagnosis and prognosis of AML.
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1943-8141
卷号	14 期号:1 页码:197-+
页数	14
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000748444800012
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	35173838
PMC记录号	PMC8829596
通讯作者地址	[Chen, Ming]Wenzhou Med Univ, Affiliated Hosp 3, Dept Blood Transfus, 108 Wansong Rd, Ruian 325200, Zhejiang, Peoples R China.
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5079
专题	其他_附属第三医院（瑞安市人民医院）
通讯作者	Chen, Ming
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 3, Dept Blood Transfus, 108 Wansong Rd, Ruian 325200, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 3, Clin Lab, Ruian 325200, Zhejiang, Peoples R China; 3.Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China
第一作者单位	附属第三医院（瑞安市人民医院）; 温州市第三临床学院（温州市人民医院）
通讯作者单位	附属第三医院（瑞安市人民医院）; 温州市第三临床学院（温州市人民医院）
第一作者的第一单位	附属第三医院（瑞安市人民医院）
推荐引用方式 GB/T 7714	Chen, Xiaohe,Zhao, Lifen,Yu, Tian,et al. SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2022,14(1):197-+.
APA	Chen, Xiaohe, Zhao, Lifen, Yu, Tian, Zeng, Jue, & Chen, Ming. (2022). SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 14(1), 197-+.
MLA	Chen, Xiaohe,et al."SPINK2 is a prognostic biomarker related to immune infiltration in acute myeloid leukemia".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 14.1(2022):197-+.