A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer

doi:10.1007/s13277-015-3435-x

科研成果详情

题名	A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer
作者	Fan, Lei 1,2; Li, Wulan1,3; Ying, Shilong 1; Shi, Lingyi 1; Wang, Zhe 1; Chen, Gaozhi1; Ye, Hui4; Wu, Xiaoping1,5; Wu, Jianzhang1; Liang, Guang1; Li, Xiaokun1
发表日期	2015-09
发表期刊	TUMOR BIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FGF2 binding Peptide derivative Half-life Non-toxicity Anti-proliferation
其他关键词	FACTOR RECEPTORS ; BFGF ; BIOAVAILABILITY ; CELLS ; TUMORIGENESIS ; TRANSITION ; EXPRESSION ; STRATEGIES ; STABILITY ; DRUGS
摘要	Fibroblast growth factor 2 (FGF2) plays a critical role in tumorigenesis and progression of solid tumor and is upregulated in gastric carcinoma serum. Therefore, it is regarded as a potential therapeutic target of human gastric cancer. Suppression of bioactivities of FGF2 may contribute to human gastric cancer therapy. Herein, we obtained a novel FGF2-binding peptide derivative (named P32), which originated from a previously isolated P7 peptide with poor stability. We proved that P32, which had a half-life in human plasma up to 12 h, enhanced stability and exerted strong inhibitory effect on FGF2-induced cell proliferation and invasion in human gastric cancer cell lines. Further investigations revealed that the underlying anti-proliferation mechanisms of P32 in vitro included arresting FGF2-stimulated cells at the G0/G1 phase and reducing the activation of AKT and Erk1/2 cascades. The FGF2-binding peptide derivative P32 has improved stability, is relatively safe, and may have therapeutic potential in FGF2-driven gastric cancer.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81102310, 81402839, 81272462]; Zhejiang Province Natural Science Funding of China [Y4110029]; Technology Foundation for Medical Science of Zhejiang Province [2012KYB127]; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Jinan University; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Guangdong Provincial Thousand-Hundred-Ten Talent Project
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	1010-4283
EISSN	1423-0380
卷号	36 期号:9 页码:7233-7241
DOI	10.1007/s13277-015-3435-x
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000365033100074
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25894376
SCOPUSEID	2-s2.0-84947129074
通讯作者地址	[Wu, Xiaoping]Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Cancer Research
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5054
专题	药学院（分析测试中心）_药学系温州医科大学基础医学院（机能实验教学中心）
通讯作者	Wu, Xiaoping
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Department of Pharmacy,Jinhua Municipal Central Hospital,Jinhua,321000,China; 3.College of Information Science and Computer Engineering,Wenzhou Medical University,Wenzhou,325035,China; 4.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 5.Institute of Tissue Transplantation and Immunology,Jinan University,Guangzhou,510632,China
第一作者单位	药学院（分析测试中心）_药学系
通讯作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心
第一作者的第一单位	药学院（分析测试中心）_药学系
推荐引用方式 GB/T 7714	Fan, Lei,Li, Wulan,Ying, Shilong,et al. A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer[J]. TUMOR BIOLOGY,2015,36(9):7233-7241.
APA	Fan, Lei., Li, Wulan., Ying, Shilong., Shi, Lingyi., Wang, Zhe., ... & Li, Xiaokun. (2015). A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer. TUMOR BIOLOGY, 36(9), 7233-7241.
MLA	Fan, Lei,et al."A peptide derivative serves as a fibroblast growth factor 2 antagonist in human gastric cancer".TUMOR BIOLOGY 36.9(2015):7233-7241.