Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population

doi:10.2217/pgs-2016-0179

科研成果详情

题名	Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population
作者	Hu, Guo-Xin1; Dai, Da-Peng 2; Wang, Hao 1; Huang, Xiang-Xin 1; Zhou, Xiao-Yang 2; Cai, Jie 3; Chen, Hao 4; Cai, Jian-Ping 2
发表日期	2017-03
发表期刊	PHARMACOGENOMICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	CYP3A4 genetic polymorphism Han Chinese population novel allelic-variants
其他关键词	SINGLE-NUCLEOTIDE POLYMORPHISMS ; RENAL-TRANSPLANT RECIPIENTS ; TACROLIMUS PHARMACOKINETICS ; CYP3A4-ASTERISK-18 ALLELE ; PROSTATE-CANCER ; ENZYME-ACTIVITY ; VARIANTS ; ASSOCIATION ; GENOTYPE ; IMPACT
摘要	Aim: To systematically investigate the genetic polymorphisms of the CYP3A4 gene in a Han Chinese population. Materials & methods: The promoter and exons of CYP3A4 gene in 1114 unrelated, healthy Han Chinese subjects were amplified and genotyped by direct sequencing. Results: In total, five previously reported alleles (1G, 4, * 5, 18B and 23) were detected, of which one allele (23) was reported for the first time in Han Chinese population. Additionally, seven novel exonic variants were also identified and designated as new alleles CYP3A4 28-*34. Conclusion: This study provides the most comprehensive data of CYP3A4 polymorphisms in Han Chinese population and detects the largest number of novel CYP3A4 alleles in one ethnic group.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371280]; National Health and Family Planning Commission of the People's Republic of China [201302008]
出版者	FUTURE MEDICINE LTD
出版地	LONDON
ISSN	1462-2416
EISSN	1744-8042
卷号	18 期号:4 页码:369-379
DOI	10.2217/pgs-2016-0179
页数	11
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000395665900006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28244811
SCOPUSEID	2-s2.0-85014417015
通讯作者地址	[Cai, Jian-Ping]MOH Key Laboratory of Geriatrics,Beijing Hospital,National Center of Gerontology,Beijing,100730,China
Scopus学科分类	Molecular Medicine;Genetics;Pharmacology
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/5046
专题	药学院（分析测试中心）药学院（分析测试中心）_临床药学与药理系
通讯作者	Cai, Jian-Ping
作者单位	1.Department of Pharmacology,School of Pharmacy,Wenzhou Medical University,Wenzhou, Zhejiang,325035,China; 2.MOH Key Laboratory of Geriatrics,Beijing Hospital,National Center of Gerontology,Beijing,100730,China; 3.Department of Pharmacy,Traditional Chinese Medical Hospital of Wenling,Wenling, Zhejiang,317500,China; 4.Department of Cardiology,Beijing Hospital,Beijing,100730,China
第一作者单位	临床药学与药理系
第一作者的第一单位	临床药学与药理系
推荐引用方式 GB/T 7714	Hu, Guo-Xin,Dai, Da-Peng,Wang, Hao,et al. Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population[J]. PHARMACOGENOMICS,2017,18(4):369-379.
APA	Hu, Guo-Xin., Dai, Da-Peng., Wang, Hao., Huang, Xiang-Xin., Zhou, Xiao-Yang., ... & Cai, Jian-Ping. (2017). Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population. PHARMACOGENOMICS, 18(4), 369-379.
MLA	Hu, Guo-Xin,et al."Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population".PHARMACOGENOMICS 18.4(2017):369-379.