Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy

doi:10.1007/s00213-018-4833-8

科研成果详情

题名	Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy
作者	Ding, Saidan1; Zhuge, Weishan 2; Hu, Jiangnan 3; Yang, Jianjing4; Wang, Xuebao5; Wen, Fangfang 1; Wang, Chengde4; Zhuge, Qichuan4
发表日期	2018-04
发表期刊	PSYCHOPHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Minimal hepatic encephalopathy Dopamine Baicalin GABA(A)R DARPP32
其他关键词	NEUROTROPHIC FACTOR ; SYNAPTIC PLASTICITY ; ALZHEIMERS-DISEASE ; NITRIC-OXIDE ; BRAIN ; RECEPTOR ; MODULATION ; ACTIVATION ; CURRENTS ; RELEASE
摘要	It has been reported that D1 receptor (D1R) activation reduces GABA(A) receptor (GABA(A)R) current, and baicalin (BAI) displays therapeutic efficacy in diseases involving cognitive impairment. We investigated the mechanisms by which BAI could improve DA-induced minimal hepatic encephalopathy (MHE) using immunoblotting, immunofluorescence, and co-immunoprecipitation. BAI did not induce toxicity on the primary cultured neurons. And no obvious toxicity of BAI to the brain was found in rats. DA activated D1R/dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein (DARPP32) to reduce the GABA(A)R current; BAI treatment did not change the D1R/DARPP32 levels but blocked DA-induced reduction of GABA(A)R levels in primary cultured neurons. DA decreased the interaction of GABA(A)R with TrkB and the expression of downstream AKT, which was blocked by BAI treatment. Moreover, BAI reversed the decrease in the expression of GABA(A)R/TrkB/AKT and prevented the impairment of synaptogenesis and memory deficits in MHE rats. These results suggest that BAI has neuroprotective and synaptoprotective effects on MHE which are not related to upstream D1R/DARPP32 signaling, but to the targeting of downstream GABA(A)R signaling to TrkB.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671042, 81300308, 81171088, 81371396]
出版者	SPRINGER
出版地	NEW YORK
ISSN	0033-3158
EISSN	1432-2072
卷号	235 期号:4 页码:1163-1178
DOI	10.1007/s00213-018-4833-8
页数	16
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000428421300020
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29404643
PMC记录号	PMC5869945
SCOPUSEID	2-s2.0-85044535500
通讯作者地址	[Zhuge, Qichuan]Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research,Neurosurgery Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China
Scopus学科分类	Pharmacology
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4991
专题	附属第一医院药学院（分析测试中心）附属第一医院_胃肠外科第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室
通讯作者	Zhuge, Qichuan
作者单位	1.Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China; 2.Gastrointestinal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China; 3.Institute for Healthy Aging,University of North Texas Health Science Center,Fort Worth,76107,United States; 4.Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research,Neurosurgery Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,325000,China; 5.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,Zhejiang,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ding, Saidan,Zhuge, Weishan,Hu, Jiangnan,et al. Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy[J]. PSYCHOPHARMACOLOGY,2018,235(4):1163-1178.
APA	Ding, Saidan., Zhuge, Weishan., Hu, Jiangnan., Yang, Jianjing., Wang, Xuebao., ... & Zhuge, Qichuan. (2018). Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy. PSYCHOPHARMACOLOGY, 235(4), 1163-1178.
MLA	Ding, Saidan,et al."Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABA(A)R-TrkB interaction in minimal hepatic encephalopathy".PSYCHOPHARMACOLOGY 235.4(2018):1163-1178.