Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis

doi:10.1002/ptr.7088

科研成果详情

题名	Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis
作者	Huang, Hao 1; Jiang, Wenli 2; Hong, Kehua 3; Cai, Jie 3; He, Yongchao 4; Ma, Xuming 3; Wu, Peng 3; Lang, Junzhe3; Ma, Yuegang 1; Huang, Caiguo 2; Yuan, Jiandong3
发表日期	2021-07
发表期刊	PHYTOTHERAPY RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	anti‐ resorptives bone resorption ERK LPS osteoclast protocatechualdehyde
其他关键词	TUMOR-NECROSIS-FACTOR ; BONE-RESORPTION ; IN-VITRO ; GENE-EXPRESSION ; C-FOS ; PROTEIN-KINASE ; UP-REGULATION ; DIFFERENTIATION ; RANKL ; NFATC1
摘要	Inflammatory osteolysis as a consequence of chronic bacterial infection underlies several lytic bone conditions, such as otitis media, osteomyelitis, septic arthritis, periodontitis, periprosthetic infection, and aseptic loosening of orthopedic implants. In consideration of the lack of effective preventive or treatments options against infectious osteolysis, the exploitation of novel pharmacological compounds/agents is critically required. The present study assessed the effect of protocatechualdehyde (PCA), a natural occurring polyphenolic compound with diverse biological activities including but not limited to antibacterial and antiinflammatory properties, on nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis in vitro and lipopolysaccharide (LPS)-induced bone loss in vivo. In the present study, it was found that PCA potently inhibited RANKL-induced osteoclast formation, fusion, and activation toward bone resorption in a dose-dependent manner via the suppression of the ERK/c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling axis. It was further demonstrated that the in vivo administration of PCA could effectively protect mice against the deleterious effects of LPS-induced calvarial bone destruction by attenuating osteoclast formation and activity in a dose-dependent manner. Collectively, these findings provided evidence for the potential therapeutic application of PCA in the prevention and treatment of infectious osteolytic conditions, and potentially other osteoclast-mediated bone diseases.
资助项目	National Key Research and Development Program of China [2028YFC0310904]
出版者	WILEY
出版地	HOBOKEN
ISSN	0951-418X
EISSN	1099-1573
卷号	35 期号:7 页码:3821-3835
DOI	10.1002/ptr.7088
页数	15
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000634006100001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33778997
SCOPUSEID	2-s2.0-85103223515
通讯作者地址	[Yuan, Jiandong]Department of Orthopedics,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4904
专题	附属第一医院_骨科其他_附属苍南医院（苍南县人民医院）
通讯作者	Yuan, Jiandong
作者单位	1.Department of Orthopedics,Shaoxing People's Hospital (Shaoxing Hospital,Zhejiang University School of Medicine),Shaoxing,China; 2.Department of Biochemistry and Molecular Biology,College of Basic Medical,Navy Medical University,Shanghai,China; 3.Department of Orthopedics,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Orthopedics,The Affiliated Cangnan Hospital of Wenzhou Medical University,Wenzhou,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Huang, Hao,Jiang, Wenli,Hong, Kehua,et al. Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis[J]. PHYTOTHERAPY RESEARCH,2021,35(7):3821-3835.
APA	Huang, Hao., Jiang, Wenli., Hong, Kehua., Cai, Jie., He, Yongchao., ... & Yuan, Jiandong. (2021). Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis. PHYTOTHERAPY RESEARCH, 35(7), 3821-3835.
MLA	Huang, Hao,et al."Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis".PHYTOTHERAPY RESEARCH 35.7(2021):3821-3835.