PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer

doi:10.3892/ol.2015.3434

科研成果详情

题名	PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer
作者	Xia, Xianghou 1; Yin, Wenjuan 2; Zhang, Xiping 1; Yu, Xingfei 1; Wang, Chen 1; Xu, Shenhua 3; Feng, Weiliang 1; Yang, Hongjian 1,4
发表日期	2015-09
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	breast cancer paired box 6 prognosis human epidermal growth factor receptor 2 progesterone receptor estrogen receptor
其他关键词	GASTRIC-CANCER ; SURVIVAL ; GROWTH ; GENE ; HYPERMETHYLATION ; EXPRESSION ; CARCINOMA ; RECEPTOR ; DISEASE ; CHINA
摘要	Paired box 6 (PAX6) plays a significant role in the development of human neuroectodermal epithelial tissues. Previous studies have suggested that the PAX6 promoter is hypermethylated in breast cancer and that it is involved in breast cancer cell proliferation. The present study aimed to investigate the expression of PAX6 in invasive breast cancer tissues, and to evaluate its prognostic significance. Immunohistochemistry (IHC) was used to detect PAX6 expression on a breast cancer tissue microarray containing tissues from 111 patients. Associations of PAX6 expression with staging and prognosis were analyzed. PAX6 was mainly expressed in the nucleus. The PAX6 staining intensity was not associated with age, histological grade, lymph node status, tumor size, or progesterone receptor and human epidermal growth factor receptor 2 expression (all P > 0.05). A high level of PAX6 staining was more frequent in estrogen receptor (ER) -negative cases compared with ER-positive cases (43.9 vs. 25.7%; P = 0.049). After a median follow-up time of 110 months, the patients with low PAX6 expression exhibited an improved survival rate compared with the patients with high PAX6 expression (P < 0.001). Cox analysis showed a worse survival rate in the patients with high PAX6 staining (hazard ratio, 3.458; 95% confidence interval, 1.575-7.593; P = 0.002). In conclusion, high tumor PAX6 staining intensity by IHC was associated with a poor prognosis in breast cancer patients.
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1082
卷号	10 期号:3 页码:1501-1506
DOI	10.3892/ol.2015.3434
页数	6
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000360923000044
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26622698
PMC记录号	PMC4533256
SCOPUSEID	2-s2.0-84937509351
通讯作者地址	[Yang, Hongjian]Department of Surgical Oncology,School of the First Clinical Medical Sciences,Wenzhou Medical University,2 Fuxue Road,Wenzhou,325000,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4874
专题	第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科
通讯作者	Yang, Hongjian
作者单位	1.Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou,China; 2.Department of Pathology,Zhejiang Cancer Hospital,Hangzhou,China; 3.Zhejiang Cancer Research Institute,Hangzhou,China; 4.Department of Surgical Oncology,School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China
通讯作者单位	温州医科大学
推荐引用方式 GB/T 7714	Xia, Xianghou,Yin, Wenjuan,Zhang, Xiping,et al. PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer[J]. ONCOLOGY LETTERS,2015,10(3):1501-1506.
APA	Xia, Xianghou., Yin, Wenjuan., Zhang, Xiping., Yu, Xingfei., Wang, Chen., ... & Yang, Hongjian. (2015). PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer. ONCOLOGY LETTERS, 10(3), 1501-1506.
MLA	Xia, Xianghou,et al."PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer".ONCOLOGY LETTERS 10.3(2015):1501-1506.