题名 | PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer |
作者 | |
发表日期 | 2015-09 |
发表期刊 | ONCOLOGY LETTERS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | breast cancer paired box 6 prognosis human epidermal growth factor receptor 2 progesterone receptor estrogen receptor |
其他关键词 | GASTRIC-CANCER ; SURVIVAL ; GROWTH ; GENE ; HYPERMETHYLATION ; EXPRESSION ; CARCINOMA ; RECEPTOR ; DISEASE ; CHINA |
摘要 | Paired box 6 (PAX6) plays a significant role in the development of human neuroectodermal epithelial tissues. Previous studies have suggested that the PAX6 promoter is hypermethylated in breast cancer and that it is involved in breast cancer cell proliferation. The present study aimed to investigate the expression of PAX6 in invasive breast cancer tissues, and to evaluate its prognostic significance. Immunohistochemistry (IHC) was used to detect PAX6 expression on a breast cancer tissue microarray containing tissues from 111 patients. Associations of PAX6 expression with staging and prognosis were analyzed. PAX6 was mainly expressed in the nucleus. The PAX6 staining intensity was not associated with age, histological grade, lymph node status, tumor size, or progesterone receptor and human epidermal growth factor receptor 2 expression (all P > 0.05). A high level of PAX6 staining was more frequent in estrogen receptor (ER) -negative cases compared with ER-positive cases (43.9 vs. 25.7%; P = 0.049). After a median follow-up time of 110 months, the patients with low PAX6 expression exhibited an improved survival rate compared with the patients with high PAX6 expression (P < 0.001). Cox analysis showed a worse survival rate in the patients with high PAX6 staining (hazard ratio, 3.458; 95% confidence interval, 1.575-7.593; P = 0.002). In conclusion, high tumor PAX6 staining intensity by IHC was associated with a poor prognosis in breast cancer patients. |
出版者 | SPANDIDOS PUBL LTD |
出版地 | ATHENS |
ISSN | 1792-1074 |
EISSN | 1792-1082 |
卷号 | 10期号:3页码:1501-1506 |
DOI | 10.3892/ol.2015.3434 |
页数 | 6 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000360923000044 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 26622698 |
PMC记录号 | PMC4533256 |
SCOPUSEID | 2-s2.0-84937509351 |
通讯作者地址 | [Yang, Hongjian]Department of Surgical Oncology,School of the First Clinical Medical Sciences,Wenzhou Medical University,2 Fuxue Road,Wenzhou,325000,China |
Scopus学科分类 | Oncology;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/4874 |
专题 | 第一临床医学院(信息与工程学院)、附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院_外科学_肿瘤外科 |
通讯作者 | Yang, Hongjian |
作者单位 | 1.Department of Breast Surgery,Zhejiang Cancer Hospital,Hangzhou,China; 2.Department of Pathology,Zhejiang Cancer Hospital,Hangzhou,China; 3.Zhejiang Cancer Research Institute,Hangzhou,China; 4.Department of Surgical Oncology,School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China |
通讯作者单位 | 温州医科大学 |
推荐引用方式 GB/T 7714 | Xia, Xianghou,Yin, Wenjuan,Zhang, Xiping,et al. PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer[J]. ONCOLOGY LETTERS,2015,10(3):1501-1506. |
APA | Xia, Xianghou., Yin, Wenjuan., Zhang, Xiping., Yu, Xingfei., Wang, Chen., ... & Yang, Hongjian. (2015). PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer. ONCOLOGY LETTERS, 10(3), 1501-1506. |
MLA | Xia, Xianghou,et al."PAX6 overexpression is associated with the poor prognosis of invasive ductal breast cancer".ONCOLOGY LETTERS 10.3(2015):1501-1506. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论