Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

doi:10.1038/cr.2009.69

科研成果详情

题名	Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
作者	Lu, Jianxin 1; Sharma, Lokendra Kumar 2; Bai, Yidong1,2
发表期刊	CELL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review
关键词	mitochondrial DNA mutation cancer ROS apoptosis
其他关键词	D-LOOP REGION ; OXYGEN-SPECIES GENERATION ; RENAL-CELL CARCINOMA ; SOMATIC MUTATIONS ; MICROSATELLITE INSTABILITY ; PROSTATE-CANCER ; COMPLEX-I ; COLORECTAL CARCINOMAS ; HYDROGEN-PEROXIDE ; DISPLACEMENT LOOP
摘要	Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA (mtDNA) mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.
资助项目	NIA/NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01 AG025223]; Wendy Will Case Cancer Fund; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG025223] Funding Source: NIH RePORTER
出版者	SPRINGERNATURE
出版地	LONDON
ISSN	1001-0602
EISSN	1748-7838
卷号	19 期号:7 页码:802-815
DOI	10.1038/cr.2009.69
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000268722200003
收录类别	SCIE ; PUBMED ; SCOPUS ; CSCD
发表日期	2009-07
学科领域	细胞生物学
URL	查看原文
CSCD记录号	CSCD:3615769
Pubmed记录号	19532122
PMC记录号	PMC4710094
Scopus记录号	2-s2.0-68149137896
自科自定义期刊分类	T2(B)类
引用统计	被引频次：188[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4839
专题	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者	Bai, Yidong
作者单位	1.Wenzhou Med Coll, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Peoples R China; 2.Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）; 检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Lu, Jianxin,Sharma, Lokendra Kumar,Bai, Yidong. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis[J]. CELL RESEARCH,2009,19(7):802-815.
APA	Lu, Jianxin, Sharma, Lokendra Kumar, & Bai, Yidong. (2009). Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. CELL RESEARCH, 19(7), 802-815.
MLA	Lu, Jianxin,et al."Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis".CELL RESEARCH 19.7(2009):802-815.