A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers

doi:10.1021/Ja305814u

科研成果详情

题名	A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers
作者	Pei, Hao 1; Li, Jiang 1; Lv, Min 1; Wang, Jingyan 1; Gao, Jimin2; Lu, Jianxin 2; Li, Yongping 1; Huang, Qing 1; Hu, Jun 1; Fan, Chunhai 1
发表期刊	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	GREEN FLUORESCENT PROTEIN ; COLORIMETRIC IDENTIFICATION ; DIFFERENTIAL RECEPTORS ; MOLECULAR RECOGNITION ; AMINO-ACIDS ; OXIDE ; DISCRIMINATION ; NANOPARTICLES ; FIELD
摘要	In this work, we report a new concept of adaptive ensemble aptamers (ENSaptamers) that exploits the collective recognition abilities of a small set of rationally designed, nonspecific DNA sequences to identify molecular or cellular targets discriminatively. In contrast to in vitro selected aptamers, which possess specific lock-and-key recognition, ENSaptamers rely on pattern recognition that mimics natural olfactory or gustatory systems. Nanographene oxide was employed to provide a low-background and highly reproducible fluorescent assay system. We demonstrate that this platform provides a highly discriminative and adaptive tool for high precision identification of a wide range of targets for diagnostic and proteomic applications with a nearly unlimited supply of ENSaptamer receptors.
资助项目	National Basic Research Program (973 Program)National Basic Research Program of China [2012CB932600]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [21075128, 20902096, 21073221, 90913014, 30928023, 30971516]; Chinese Academy of SciencesChinese Academy of Sciences
出版者	AMER CHEMICAL SOC
出版地	WASHINGTON
ISSN	0002-7863
卷号	134 期号:33 页码:13843-13849
DOI	10.1021/Ja305814u
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000307699000045
收录类别	SCIE ; SCOPUS
发表日期	2012-08-22
URL	查看原文
Scopus记录号	2-s2.0-84865441051
自科自定义期刊分类	T3(A)类
引用统计	被引频次：210[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4527
专题	温州医科大学
通讯作者	Hu, Jun
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China; 2.Wenzhou Med Coll, Minist Educ, Key Lab Lab Med, Wenzhou 325035, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Pei, Hao,Li, Jiang,Lv, Min,et al. A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(33):13843-13849.
APA	Pei, Hao., Li, Jiang., Lv, Min., Wang, Jingyan., Gao, Jimin., ... & Fan, Chunhai. (2012). A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(33), 13843-13849.
MLA	Pei, Hao,et al."A Graphene-Based Sensor Array for High-Precision and Adaptive Target Identification with Ensemble Aptamers".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 134.33(2012):13843-13849.