Opposite effects on tumor growth depending on dose of Achyranthes bidentata polysaccharides in C57BL/6 mice

doi:10.1016/j.intimp.2006.12.009

科研成果详情

题名	Opposite effects on tumor growth depending on dose of Achyranthes bidentata polysaccharides in C57BL/6 mice
作者	Jin, Li-Qin ; Zheng, Zhao-Jing ; Peng, Ying ; Li, Wei-Xing ; Chen, Xiao-Ming ; Lu, Jian-Xin
发表日期	2007-05
发表期刊	INTERNATIONAL IMMUNOPHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Achyranthes bidentata polysaccharides (ABPS) Lewis lung cancer (LLC) NK cytokine mRNA cell cycle
其他关键词	NECROSIS-FACTOR-ALPHA ; COLORECTAL-CANCER ; NATURAL-KILLER ; CELL-CYCLE ; S-PHASE ; INTERLEUKIN-6 ; PROLIFERATION ; APOPTOSIS ; CYTOKINES
摘要	We report here the investigation on the effects of Achyranthes bidentata polysaccharides (ABPS) against Lewis lung cancer (LLC in C57BL/6 mice. Depending on its doses administered in vivo, ABPS was shown to have inhibitory as well as stimulative effects on tumor growth in LLC-bearing C57BL/6 mice. ABPS at low dose could significantly inhibit LLC growth, while high dose treatment of ABPS stimulated, rather than inhibited, LLC growth in C57BL/6 mice. Tumor cell cycle analysis revealed that more tumor cells arrested at G2/M phase after daily low dose intraperitoneal injection of ABPS for consecutive 15 days. The spleen weight increased markedly in LLC-bearing C57BL/6 mice treated. with high dose of ABPS. However, the spleen cytotoxicity activity was significantly despaired in mice of high dose treatment of ABPS. Furthermore, we demonstrated that the expressions of IL-6 mRNA and TNF-alpha mRNA were markedly up-regulated in spleens from mice treated with a high dose of ABPS by RT-PCR reactions, suggesting that the low dose of ABPS inhibits tumor growth via its effect on tumor cell cycle distribution, rather than activation of NK activity as previously suggested. We postulate that the stimulation of tumor growth by high dose of ABPS is associated with dysfunction of NK cell and up-regulation of IL-6 mRNA and TNF-alpha mRNA expression in murine spleen. (c) 2007 Elsevier B.V. All rights reserved.
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	1567-5769
EISSN	1878-1705
卷号	7 期号:5 页码:568-577
DOI	10.1016/j.intimp.2006.12.009
页数	10
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:000245971800002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	17386404
SCOPUSEID	2-s2.0-33947405149
通讯作者地址	[Lu, Jian-Xin]Wenzhou Med Coll, Inst Cellular & Mol Med, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China.
TOP期刊	TOP期刊
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/4471
专题	检验医学院（生命科学学院、生物学实验教学中心）_细胞与分子生物医学研究所检验医学院（生命科学学院、生物学实验教学中心）
通讯作者	Lu, Jian-Xin
作者单位	1.Wenzhou Med Coll, Inst Cellular & Mol Med, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Coll, Sch Life Sci, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China; 3.Zhejiang Prov Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）_细胞与分子生物医学研究所
推荐引用方式 GB/T 7714	Jin, Li-Qin,Zheng, Zhao-Jing,Peng, Ying,et al. Opposite effects on tumor growth depending on dose of Achyranthes bidentata polysaccharides in C57BL/6 mice[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2007,7(5):568-577.
APA	Jin, Li-Qin, Zheng, Zhao-Jing, Peng, Ying, Li, Wei-Xing, Chen, Xiao-Ming, & Lu, Jian-Xin. (2007). Opposite effects on tumor growth depending on dose of Achyranthes bidentata polysaccharides in C57BL/6 mice. INTERNATIONAL IMMUNOPHARMACOLOGY, 7(5), 568-577.
MLA	Jin, Li-Qin,et al."Opposite effects on tumor growth depending on dose of Achyranthes bidentata polysaccharides in C57BL/6 mice".INTERNATIONAL IMMUNOPHARMACOLOGY 7.5(2007):568-577.